Human papillomavirus-related multiphenotypic sinonasal carcinoma

From Libre Pathology
Revision as of 16:20, 14 November 2021 by Michael (talk | contribs) (→‎IHC)
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to navigation Jump to search

Human papillomavirus-related multiphenotypic sinonasal carcinoma, abbreviated HPV-related multiphenotypic sinonasal carcinoma, is a rare malignant tumour of the head and neck.[1]

It is also known as human papillomavirus-related carcinoma with adenoid cystic-like features (abbreviated HPV-related carcinoma with AdCC-like features).[2]




  • Adenoid cystic carcinoma-like morphology with:
    • Squamous dysplasia of surface epithelium.
    • Squamous differentiation within tumour.




  • p16 +ve in >= 75% of cells.[5]
  • SOX10 +ve (4 of 4[6]).

See also


  1. Bishop, JA.; Andreasen, S.; Hang, JF.; Bullock, MJ.; Chen, TY.; Franchi, A.; Garcia, JJ.; Gnepp, DR. et al. (Dec 2017). "HPV-related Multiphenotypic Sinonasal Carcinoma: An Expanded Series of 49 Cases of the Tumor Formerly Known as HPV-related Carcinoma With Adenoid Cystic Carcinoma-like Features.". Am J Surg Pathol 41 (12): 1690-1701. doi:10.1097/PAS.0000000000000944. PMID 28877065.
  2. Andreasen, S.; Bishop, JA.; Hansen, TV.; Westra, WH.; Bilde, A.; von Buchwald, C.; Kiss, K. (May 2017). "Human papillomavirus-related carcinoma with adenoid cystic-like features of the sinonasal tract: clinical and morphological characterization of six new cases.". Histopathology 70 (6): 880-888. doi:10.1111/his.13162. PMID 28035703.
  3. Bishop, JA.; Ogawa, T.; Stelow, EB.; Moskaluk, CA.; Koch, WM.; Pai, SI.; Westra, WH. (Jun 2013). "Human papillomavirus-related carcinoma with adenoid cystic-like features: a peculiar variant of head and neck cancer restricted to the sinonasal tract.". Am J Surg Pathol 37 (6): 836-44. doi:10.1097/PAS.0b013e31827b1cd6. PMID 23598962.
  4. Oramas DM, Bell D, Middleton LP (November 2020). "Sinonasal analogue HPV related breast multiphenotypic carcinoma, a report of a case with the first description in the breast". Diagn Pathol 15 (1): 137. doi:10.1186/s13000-020-01050-7. PMC 7678216. PMID 33218360.
  5. Hang, JF.; Hsieh, MS.; Li, WY.; Chen, JY.; Lin, SY.; Liu, SH.; Pan, CC.; Kuo, YJ. (Jun 2017). "Human Papillomavirus-related Carcinoma with Adenoid Cystic-like Features: A Series of 5 Cases Expanding the Pathologic Spectrum.". Histopathology. doi:10.1111/his.13301. PMID 28664668.
  6. Rupp NJ, Camenisch U, Seidl K, Rushing EJ, Anderegg N, Broglie MA, Holzmann D, Morand GB (September 2020). "HPV-Related Multiphenotypic Sinonasal Carcinoma: Four Cases that Expand the Morpho-Molecular Spectrum and Include Occupational Data". Head Neck Pathol 14 (3): 623–629. doi:10.1007/s12105-019-01079-1. PMC 7413931. PMID 31571045.