Human papillomavirus-related multiphenotypic sinonasal carcinoma

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Human papillomavirus-related carcinoma with adenoid cystic-like features, abbreviated HPV-related carcinoma with AdCC-like features,[1] is a rare malignant tumour of the head and neck.

General

  • Very rare diagnosis - recently described.[2]
  • Associated with HPV.

Microscopic

Features:

  • Adenoid cystic carcinoma-like morphology with:
    • Squamous dysplasia of surface epithelium
    • Squamous dfferentiation within tumour

Notes:

  • Perineural invasion rare.
  • Bony invasion rare.

DDx:

IHC

  • p16 +ve in >= 75% of cells.[3]

See also

References

  1. Andreasen, S.; Bishop, JA.; Hansen, TV.; Westra, WH.; Bilde, A.; von Buchwald, C.; Kiss, K. (May 2017). "Human papillomavirus-related carcinoma with adenoid cystic-like features of the sinonasal tract: clinical and morphological characterization of six new cases.". Histopathology 70 (6): 880-888. doi:10.1111/his.13162. PMID 28035703.
  2. Bishop, JA.; Ogawa, T.; Stelow, EB.; Moskaluk, CA.; Koch, WM.; Pai, SI.; Westra, WH. (Jun 2013). "Human papillomavirus-related carcinoma with adenoid cystic-like features: a peculiar variant of head and neck cancer restricted to the sinonasal tract.". Am J Surg Pathol 37 (6): 836-44. doi:10.1097/PAS.0b013e31827b1cd6. PMID 23598962.
  3. Hang, JF.; Hsieh, MS.; Li, WY.; Chen, JY.; Lin, SY.; Liu, SH.; Pan, CC.; Kuo, YJ. (Jun 2017). "Human Papillomavirus-related Carcinoma with Adenoid Cystic-like Features: A Series of 5 Cases Expanding the Pathologic Spectrum.". Histopathology. doi:10.1111/his.13301. PMID 28664668.