Human papillomavirus-related multiphenotypic sinonasal carcinoma
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Human papillomavirus-related carcinoma with adenoid cystic-like features, abbreviated HPV-related carcinoma with AdCC-like features is a rare malignant tumour of the head and neck.
General
- Very rare diagnosis - recently described.[1]
Microscopic
Features:
- Adenoid cystic carcinoma-like morphology with:
- Squamous dysplasia of surface epithelium
- Squamous dfferentiation within tumour
Notes:
- Perineural invasion rare.
- Bony invasion rare.
DDx:
IHC
- p16 +ve in >= 75% of cells.[2]
References
- ↑ Bishop, JA.; Ogawa, T.; Stelow, EB.; Moskaluk, CA.; Koch, WM.; Pai, SI.; Westra, WH. (Jun 2013). "Human papillomavirus-related carcinoma with adenoid cystic-like features: a peculiar variant of head and neck cancer restricted to the sinonasal tract.". Am J Surg Pathol 37 (6): 836-44. doi:10.1097/PAS.0b013e31827b1cd6. PMID 23598962.
- ↑ Hang, JF.; Hsieh, MS.; Li, WY.; Chen, JY.; Lin, SY.; Liu, SH.; Pan, CC.; Kuo, YJ. (Jun 2017). "Human Papillomavirus-related Carcinoma with Adenoid Cystic-like Features: A Series of 5 Cases Expanding the Pathologic Spectrum.". Histopathology. doi:10.1111/his.13301. PMID 28664668.