Difference between revisions of "Human papillomavirus-related multiphenotypic sinonasal carcinoma"

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'''Human papillomavirus-related carcinoma with adenoid cystic-like features''', abbreviated '''HPV-related carcinoma with AdCC-like features''',<ref name=pmid28035703>{{Cite journal  | last1 = Andreasen | first1 = S. | last2 = Bishop | first2 = JA. | last3 = Hansen | first3 = TV. | last4 = Westra | first4 = WH. | last5 = Bilde | first5 = A. | last6 = von Buchwald | first6 = C. | last7 = Kiss | first7 = K. | title = Human papillomavirus-related carcinoma with adenoid cystic-like features of the sinonasal tract: clinical and morphological characterization of six new cases. | journal = Histopathology | volume = 70 | issue = 6 | pages = 880-888 | month = May | year = 2017 | doi = 10.1111/his.13162 | PMID = 28035703 }}</ref> is a rare [[cancer|malignant]] tumour of the [[head and neck pathology|head and neck]].
'''Human papillomavirus-related multiphenotypic sinonasal carcinoma''', abbreviated '''HPV-related multiphenotypic sinonasal carcinoma''', is a rare [[cancer|malignant]] tumour of the [[head and neck pathology|head and neck]].<ref>{{Cite journal  | last1 = Bishop | first1 = JA. | last2 = Andreasen | first2 = S. | last3 = Hang | first3 = JF. | last4 = Bullock | first4 = MJ. | last5 = Chen | first5 = TY. | last6 = Franchi | first6 = A. | last7 = Garcia | first7 = JJ. | last8 = Gnepp | first8 = DR. | last9 = Gomez-Fernandez | first9 = CR. | title = HPV-related Multiphenotypic Sinonasal Carcinoma: An Expanded Series of 49 Cases of the Tumor Formerly Known as HPV-related Carcinoma With Adenoid Cystic Carcinoma-like Features. | journal = Am J Surg Pathol | volume = 41 | issue = 12 | pages = 1690-1701 | month = Dec | year = 2017 | doi = 10.1097/PAS.0000000000000944 | PMID = 28877065 }}</ref>
 
It is also known as '''human papillomavirus-related carcinoma with adenoid cystic-like features''' (abbreviated '''HPV-related carcinoma with AdCC-like features''').<ref name=pmid28035703>{{Cite journal  | last1 = Andreasen | first1 = S. | last2 = Bishop | first2 = JA. | last3 = Hansen | first3 = TV. | last4 = Westra | first4 = WH. | last5 = Bilde | first5 = A. | last6 = von Buchwald | first6 = C. | last7 = Kiss | first7 = K. | title = Human papillomavirus-related carcinoma with adenoid cystic-like features of the sinonasal tract: clinical and morphological characterization of six new cases. | journal = Histopathology | volume = 70 | issue = 6 | pages = 880-888 | month = May | year = 2017 | doi = 10.1111/his.13162 | PMID = 28035703 }}</ref>  
==General==
==General==
*Very rare diagnosis - recently described.<ref>{{Cite journal  | last1 = Bishop | first1 = JA. | last2 = Ogawa | first2 = T. | last3 = Stelow | first3 = EB. | last4 = Moskaluk | first4 = CA. | last5 = Koch | first5 = WM. | last6 = Pai | first6 = SI. | last7 = Westra | first7 = WH. | title = Human papillomavirus-related carcinoma with adenoid cystic-like features: a peculiar variant of head and neck cancer restricted to the sinonasal tract. | journal = Am J Surg Pathol | volume = 37 | issue = 6 | pages = 836-44 | month = Jun | year = 2013 | doi = 10.1097/PAS.0b013e31827b1cd6 | PMID = 23598962 }}</ref>
*Very rare diagnosis - recently described.<ref>{{Cite journal  | last1 = Bishop | first1 = JA. | last2 = Ogawa | first2 = T. | last3 = Stelow | first3 = EB. | last4 = Moskaluk | first4 = CA. | last5 = Koch | first5 = WM. | last6 = Pai | first6 = SI. | last7 = Westra | first7 = WH. | title = Human papillomavirus-related carcinoma with adenoid cystic-like features: a peculiar variant of head and neck cancer restricted to the sinonasal tract. | journal = Am J Surg Pathol | volume = 37 | issue = 6 | pages = 836-44 | month = Jun | year = 2013 | doi = 10.1097/PAS.0b013e31827b1cd6 | PMID = 23598962 }}</ref>
*Associated with [[HPV]].
*Associated with [[human papillomavirus]] (HPV).


==Microscopic==
==Microscopic==
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DDx:
DDx:
*[[Adenoid cystic carcinoma]].
*[[Adenoid cystic carcinoma]].
*Basaloid [[Squamous cell carcinoma of the head and neck|squamous cell carcinoma]].


==IHC==
==IHC==
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==See also==
==See also==
*[[Salivary gland tumours]].
*[[Salivary gland tumours]].
*[[Biphenotypic sinonasal sarcoma]].


==References==
==References==

Revision as of 17:15, 29 October 2020

Human papillomavirus-related multiphenotypic sinonasal carcinoma, abbreviated HPV-related multiphenotypic sinonasal carcinoma, is a rare malignant tumour of the head and neck.[1]

It is also known as human papillomavirus-related carcinoma with adenoid cystic-like features (abbreviated HPV-related carcinoma with AdCC-like features).[2]

General

Microscopic

Features:

  • Adenoid cystic carcinoma-like morphology with:
    • Squamous dysplasia of surface epithelium.
    • Squamous differentiation within tumour.

Notes:

DDx:

IHC

  • p16 +ve in >= 75% of cells.[4]

See also

References

  1. Bishop, JA.; Andreasen, S.; Hang, JF.; Bullock, MJ.; Chen, TY.; Franchi, A.; Garcia, JJ.; Gnepp, DR. et al. (Dec 2017). "HPV-related Multiphenotypic Sinonasal Carcinoma: An Expanded Series of 49 Cases of the Tumor Formerly Known as HPV-related Carcinoma With Adenoid Cystic Carcinoma-like Features.". Am J Surg Pathol 41 (12): 1690-1701. doi:10.1097/PAS.0000000000000944. PMID 28877065.
  2. Andreasen, S.; Bishop, JA.; Hansen, TV.; Westra, WH.; Bilde, A.; von Buchwald, C.; Kiss, K. (May 2017). "Human papillomavirus-related carcinoma with adenoid cystic-like features of the sinonasal tract: clinical and morphological characterization of six new cases.". Histopathology 70 (6): 880-888. doi:10.1111/his.13162. PMID 28035703.
  3. Bishop, JA.; Ogawa, T.; Stelow, EB.; Moskaluk, CA.; Koch, WM.; Pai, SI.; Westra, WH. (Jun 2013). "Human papillomavirus-related carcinoma with adenoid cystic-like features: a peculiar variant of head and neck cancer restricted to the sinonasal tract.". Am J Surg Pathol 37 (6): 836-44. doi:10.1097/PAS.0b013e31827b1cd6. PMID 23598962.
  4. Hang, JF.; Hsieh, MS.; Li, WY.; Chen, JY.; Lin, SY.; Liu, SH.; Pan, CC.; Kuo, YJ. (Jun 2017). "Human Papillomavirus-related Carcinoma with Adenoid Cystic-like Features: A Series of 5 Cases Expanding the Pathologic Spectrum.". Histopathology. doi:10.1111/his.13301. PMID 28664668.