Difference between revisions of "Human papillomavirus-related multiphenotypic sinonasal carcinoma"
Jump to navigation
Jump to search
(→IHC) |
|||
| Line 1: | Line 1: | ||
'''Human papillomavirus-related carcinoma with adenoid cystic-like features''', abbreviated '''HPV-related carcinoma with AdCC-like features''' is a rare malignant tumour of the [[head and neck pathology|head and neck]]. | '''Human papillomavirus-related carcinoma with adenoid cystic-like features''', abbreviated '''HPV-related carcinoma with AdCC-like features''',<ref name=pmid28035703>{{Cite journal | last1 = Andreasen | first1 = S. | last2 = Bishop | first2 = JA. | last3 = Hansen | first3 = TV. | last4 = Westra | first4 = WH. | last5 = Bilde | first5 = A. | last6 = von Buchwald | first6 = C. | last7 = Kiss | first7 = K. | title = Human papillomavirus-related carcinoma with adenoid cystic-like features of the sinonasal tract: clinical and morphological characterization of six new cases. | journal = Histopathology | volume = 70 | issue = 6 | pages = 880-888 | month = May | year = 2017 | doi = 10.1111/his.13162 | PMID = 28035703 }}</ref> | ||
is a rare malignant tumour of the [[head and neck pathology|head and neck]]. | |||
==General== | ==General== | ||
*Very rare diagnosis - recently described.<ref>{{Cite journal | last1 = Bishop | first1 = JA. | last2 = Ogawa | first2 = T. | last3 = Stelow | first3 = EB. | last4 = Moskaluk | first4 = CA. | last5 = Koch | first5 = WM. | last6 = Pai | first6 = SI. | last7 = Westra | first7 = WH. | title = Human papillomavirus-related carcinoma with adenoid cystic-like features: a peculiar variant of head and neck cancer restricted to the sinonasal tract. | journal = Am J Surg Pathol | volume = 37 | issue = 6 | pages = 836-44 | month = Jun | year = 2013 | doi = 10.1097/PAS.0b013e31827b1cd6 | PMID = 23598962 }}</ref> | *Very rare diagnosis - recently described.<ref>{{Cite journal | last1 = Bishop | first1 = JA. | last2 = Ogawa | first2 = T. | last3 = Stelow | first3 = EB. | last4 = Moskaluk | first4 = CA. | last5 = Koch | first5 = WM. | last6 = Pai | first6 = SI. | last7 = Westra | first7 = WH. | title = Human papillomavirus-related carcinoma with adenoid cystic-like features: a peculiar variant of head and neck cancer restricted to the sinonasal tract. | journal = Am J Surg Pathol | volume = 37 | issue = 6 | pages = 836-44 | month = Jun | year = 2013 | doi = 10.1097/PAS.0b013e31827b1cd6 | PMID = 23598962 }}</ref> | ||
*Associated with [[HPV]]. | |||
==Microscopic== | ==Microscopic== | ||
| Line 19: | Line 20: | ||
==IHC== | ==IHC== | ||
*p16 +ve in >= 75% of cells.<ref name=pmid28664668>{{Cite journal | last1 = Hang | first1 = JF. | last2 = Hsieh | first2 = MS. | last3 = Li | first3 = WY. | last4 = Chen | first4 = JY. | last5 = Lin | first5 = SY. | last6 = Liu | first6 = SH. | last7 = Pan | first7 = CC. | last8 = Kuo | first8 = YJ. | title = Human Papillomavirus-related Carcinoma with Adenoid Cystic-like Features: A Series of 5 Cases Expanding the Pathologic Spectrum. | journal = Histopathology | volume = | issue = | pages = | month = Jun | year = 2017 | doi = 10.1111/his.13301 | PMID = 28664668 }}</ref> | *p16 +ve in >= 75% of cells.<ref name=pmid28664668>{{Cite journal | last1 = Hang | first1 = JF. | last2 = Hsieh | first2 = MS. | last3 = Li | first3 = WY. | last4 = Chen | first4 = JY. | last5 = Lin | first5 = SY. | last6 = Liu | first6 = SH. | last7 = Pan | first7 = CC. | last8 = Kuo | first8 = YJ. | title = Human Papillomavirus-related Carcinoma with Adenoid Cystic-like Features: A Series of 5 Cases Expanding the Pathologic Spectrum. | journal = Histopathology | volume = | issue = | pages = | month = Jun | year = 2017 | doi = 10.1111/his.13301 | PMID = 28664668 }}</ref> | ||
==See also== | |||
*[[Salivary gland tumours]]. | |||
==References== | ==References== | ||
| Line 24: | Line 28: | ||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Head and neck pathology]] | |||
Revision as of 15:53, 6 September 2017
Human papillomavirus-related carcinoma with adenoid cystic-like features, abbreviated HPV-related carcinoma with AdCC-like features,[1]
is a rare malignant tumour of the head and neck.
General
Microscopic
Features:
- Adenoid cystic carcinoma-like morphology with:
- Squamous dysplasia of surface epithelium
- Squamous dfferentiation within tumour
Notes:
- Perineural invasion rare.
- Bony invasion rare.
DDx:
IHC
- p16 +ve in >= 75% of cells.[3]
See also
References
- ↑ Andreasen, S.; Bishop, JA.; Hansen, TV.; Westra, WH.; Bilde, A.; von Buchwald, C.; Kiss, K. (May 2017). "Human papillomavirus-related carcinoma with adenoid cystic-like features of the sinonasal tract: clinical and morphological characterization of six new cases.". Histopathology 70 (6): 880-888. doi:10.1111/his.13162. PMID 28035703.
- ↑ Bishop, JA.; Ogawa, T.; Stelow, EB.; Moskaluk, CA.; Koch, WM.; Pai, SI.; Westra, WH. (Jun 2013). "Human papillomavirus-related carcinoma with adenoid cystic-like features: a peculiar variant of head and neck cancer restricted to the sinonasal tract.". Am J Surg Pathol 37 (6): 836-44. doi:10.1097/PAS.0b013e31827b1cd6. PMID 23598962.
- ↑ Hang, JF.; Hsieh, MS.; Li, WY.; Chen, JY.; Lin, SY.; Liu, SH.; Pan, CC.; Kuo, YJ. (Jun 2017). "Human Papillomavirus-related Carcinoma with Adenoid Cystic-like Features: A Series of 5 Cases Expanding the Pathologic Spectrum.". Histopathology. doi:10.1111/his.13301. PMID 28664668.