Human papillomavirus-associated head and neck squamous cell carcinoma
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Human papillomavirus-associated head and neck squamous cell carcinoma, abbreviated HPV-associated SCC and HPV-NHSCC, is a type of head and neck squamous cell carcinoma.
Human papillomavirus-associated head and neck squamous cell carcinoma | |
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Diagnosis in short | |
Poorly differentiated squamous cell carcinoma (SCC) that is p16 positive, compatible with HPV-associated head and neck SCC. H&E stain. | |
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LM | typically non-keratinizing squamous cell carcinoma |
LM DDx | squamous dysplasia of the head and neck, squamous cell carcinoma of the head and neck, nasopharyngeal carcinoma |
IHC | p16 +ve, EBV-ve, p63 +ve, CK5/6 +ve |
Molecular | EBER -ve |
Gross | palatine tonsil, lingual tonsil, oropharynx |
Site | head and neck |
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Clinical history | typically male, younger than typical H&N SCC, +/-homosexual practices |
Prevalence | uncommon |
Prognosis | good compared to usu. head and neck SCC |
It has a unique epidemiology, when compared to conventional head and neck squamous cell carcinoma.
Human papillomavirus-associated head and neck cancer redirects here.
General
Gross
Classic locations:
- Tonsil and base of tongue[6] (palatine tonsil, lingual tonsil, oropharynx).
Note:
- Memory device:
- Where the tip of the penis goes when someone is deep throating.
Microscopic
Features:[7]
- Typically non-keratinizing squamous cell carcinoma.
DDx:
- HPV-negative squamous cell carcinoma - see squamous cell carcinoma of the head and neck.
- Nasopharyngeal carcinoma.
Images
Case 1
Case 2
www
IHC
- p16 +ve[6] - should be >70% of cells, strong, nuclear and cytoplasmic staining.
- EBV -ve.
- CK5/6 +ve.
- p63 +ve.
A panel:
- p16, CK5/6, CK34betaE12, CD56, synaptophysin, LCA, Ki-67.
Molecular
- EBER -ve.
- Positive in nasopharyngeal carcinoma.
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BASE OF LEFT TONSIL, BIOPSY: - INVASIVE SQUAMOUS CELL CARCINOMA, POORLY DIFFERENTIATED, SEE COMMENT. COMMENT: The tumour is p16 positive and EBV negative; this favours a HPV-associated squamous cell carcinoma. Clinical correlation is suggested. The tumour stains as follows: POSITIVE: p63, CK5/6, BCL2. NEGATIVE: LCA, EBV, synaptophysin, chromogranin, CD56. PROLIFERATION (Ki-67): 90% of tumour cells.
See also
References
- ↑ 1.0 1.1 Wang, XI.; Thomas, J.; Zhang, S. (Jan 2012). "Changing trends in human papillomavirus-associated head and neck squamous cell carcinoma.". Ann Diagn Pathol 16 (1): 7-12. doi:10.1016/j.anndiagpath.2011.07.003. PMID 22001331.
- ↑ Wittekindt, C.; Wagner, S.; Klussmann, JP. (Sep 2011). "[HPV-associated head and neck cancer. The basics of molecular and translational research].". HNO 59 (9): 885-92. doi:10.1007/s00106-011-2357-1. PMID 21769577.
- ↑ Ajila, V.; Shetty, H.; Babu, S.; Shetty, V.; Hegde, S. (2015). "Human Papilloma Virus Associated Squamous Cell Carcinoma of the Head and Neck.". J Sex Transm Dis 2015: 791024. doi:10.1155/2015/791024. PMID 26483987.
- ↑ Benson, E.; Li, R.; Eisele, D.; Fakhry, C. (Jun 2014). "The clinical impact of HPV tumor status upon head and neck squamous cell carcinomas.". Oral Oncol 50 (6): 565-74. doi:10.1016/j.oraloncology.2013.09.008. PMID 24134947.
- ↑ Vourexakis, Z.; Dulguerov, P. (Oct 2011). "[HPV associated head and neck cancers].". Rev Med Suisse 7 (311): 1919-22. PMID 22046680.
- ↑ 6.0 6.1 Heath, S.; Willis, V.; Allan, K.; Purdie, K.; Harwood, C.; Shields, P.; Simcock, R.; Williams, T. et al. (Feb 2012). "Clinically significant human papilloma virus in squamous cell carcinoma of the head and neck in UK practice.". Clin Oncol (R Coll Radiol) 24 (1): e18-23. doi:10.1016/j.clon.2011.05.007. PMID 21752613.
- ↑ Chernock, RD.; El-Mofty, SK.; Thorstad, WL.; Parvin, CA.; Lewis, JS. (Sep 2009). "HPV-related nonkeratinizing squamous cell carcinoma of the oropharynx: utility of microscopic features in predicting patient outcome.". Head Neck Pathol 3 (3): 186-94. doi:10.1007/s12105-009-0126-1. PMC 2811624. PMID 20596971. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811624/.