Difference between revisions of "Human papillomavirus-associated head and neck squamous cell carcinoma"
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==IHC== | ==IHC== | ||
*p16 +ve.<ref name=pmid21752613>{{Cite journal | last1 = Heath | first1 = S. | last2 = Willis | first2 = V. | last3 = Allan | first3 = K. | last4 = Purdie | first4 = K. | last5 = Harwood | first5 = C. | last6 = Shields | first6 = P. | last7 = Simcock | first7 = R. | last8 = Williams | first8 = T. | last9 = Gilbert | first9 = DC. | title = Clinically significant human papilloma virus in squamous cell carcinoma of the head and neck in UK practice. | journal = Clin Oncol (R Coll Radiol) | volume = 24 | issue = 1 | pages = e18-23 | month = Feb | year = 2012 | doi = 10.1016/j.clon.2011.05.007 | PMID = 21752613 }}</ref> | *p16 +ve.<ref name=pmid21752613>{{Cite journal | last1 = Heath | first1 = S. | last2 = Willis | first2 = V. | last3 = Allan | first3 = K. | last4 = Purdie | first4 = K. | last5 = Harwood | first5 = C. | last6 = Shields | first6 = P. | last7 = Simcock | first7 = R. | last8 = Williams | first8 = T. | last9 = Gilbert | first9 = DC. | title = Clinically significant human papilloma virus in squamous cell carcinoma of the head and neck in UK practice. | journal = Clin Oncol (R Coll Radiol) | volume = 24 | issue = 1 | pages = e18-23 | month = Feb | year = 2012 | doi = 10.1016/j.clon.2011.05.007 | PMID = 21752613 }}</ref> | ||
*EBV -ve. | |||
*CK5/6 +ve. | |||
*p63 +ve. | |||
==Molecular== | |||
*EBER -ve. | *EBER -ve. | ||
==Sign out== | |||
<pre> | |||
BASE OF LEFT TONSIL, BIOPSY: | |||
- INVASIVE SQUAMOUS CELL CARCINOMA, POORLY DIFFERENTIATED, SEE COMMENT. | |||
COMMENT: | |||
The tumour is p16 positive and EBV negative; this favours a HPV-associated | |||
squamous cell carcinoma. Clinical correlation is suggested. | |||
The tumour stains as follows: | |||
POSITIVE: p63, CK5/6, BCL2. | |||
NEGATIVE: LCA, EBV, synaptophysin, chromogranin, CD56. | |||
PROLIFERATION (Ki-67): 90% of tumour cells. | |||
</pre> | |||
==See also== | ==See also== | ||
*[[Head and neck pathology]]. | *[[Head and neck pathology]]. |
Revision as of 20:43, 2 June 2014
Human papillomavirus-associated head and neck squamous cell carcinoma | |
---|---|
Diagnosis in short | |
| |
LM | typically non-keratinizing squamous cell carcinoma |
LM DDx | squamous dysplasia of the head and neck, squamous cell carcinoma of the head and neck, nasopharyngeal carcinoma |
IHC | p16 +ve, EBER -ve, p63 +ve, CK5/6 +ve |
Gross | palatine tonsil, lingual tonsil, oropharynx |
Site | head and neck |
| |
Clinical history | typically male |
Prevalence | uncommon |
Prognosis | good compared to usu. head and neck SCC |
Human papillomavirus-associated head and neck squamous cell carcinoma, abbreviated HPV-associated SCC and HPV-NHSCC, is a type of head and neck squamous cell carcinoma.
It has a unique epidemiology, when compared to conventional head and neck squamous cell carcinoma.
General
- Tumours associated with high risk HPV, typically HPV 16.[1]
- Lesions more radiosensitive and usually have a better prognosis.[1]
Gross
Classic locations:
- Tonsil and base of tongue[4] (palatine tonsil, lingual tonsil, oropharynx).
Note:
- Memory device:
- Where the tip of the penis goes when someone is deep throating.
Microscopic
Features:[5]
- Typically non-keratinizing squamous cell carcinoma.
DDx:
- HPV-negative squamous cell carcinoma - see squamous cell carcinoma of the head and neck.
- Nasopharyngeal carcinoma.
Images:
IHC
- p16 +ve.[4]
- EBV -ve.
- CK5/6 +ve.
- p63 +ve.
Molecular
- EBER -ve.
Sign out
BASE OF LEFT TONSIL, BIOPSY: - INVASIVE SQUAMOUS CELL CARCINOMA, POORLY DIFFERENTIATED, SEE COMMENT. COMMENT: The tumour is p16 positive and EBV negative; this favours a HPV-associated squamous cell carcinoma. Clinical correlation is suggested. The tumour stains as follows: POSITIVE: p63, CK5/6, BCL2. NEGATIVE: LCA, EBV, synaptophysin, chromogranin, CD56. PROLIFERATION (Ki-67): 90% of tumour cells.
See also
- Head and neck pathology.
- Squamous cell carcinoma.
- Nasopharyngeal carcinoma.
- Squamous cell carcinoma of the head and neck.
References
- ↑ 1.0 1.1 Wang, XI.; Thomas, J.; Zhang, S. (Jan 2012). "Changing trends in human papillomavirus-associated head and neck squamous cell carcinoma.". Ann Diagn Pathol 16 (1): 7-12. doi:10.1016/j.anndiagpath.2011.07.003. PMID 22001331.
- ↑ Wittekindt, C.; Wagner, S.; Klussmann, JP. (Sep 2011). "[HPV-associated head and neck cancer. The basics of molecular and translational research].". HNO 59 (9): 885-92. doi:10.1007/s00106-011-2357-1. PMID 21769577.
- ↑ Vourexakis, Z.; Dulguerov, P. (Oct 2011). "[HPV associated head and neck cancers].". Rev Med Suisse 7 (311): 1919-22. PMID 22046680.
- ↑ 4.0 4.1 Heath, S.; Willis, V.; Allan, K.; Purdie, K.; Harwood, C.; Shields, P.; Simcock, R.; Williams, T. et al. (Feb 2012). "Clinically significant human papilloma virus in squamous cell carcinoma of the head and neck in UK practice.". Clin Oncol (R Coll Radiol) 24 (1): e18-23. doi:10.1016/j.clon.2011.05.007. PMID 21752613.
- ↑ Chernock, RD.; El-Mofty, SK.; Thorstad, WL.; Parvin, CA.; Lewis, JS. (Sep 2009). "HPV-related nonkeratinizing squamous cell carcinoma of the oropharynx: utility of microscopic features in predicting patient outcome.". Head Neck Pathol 3 (3): 186-94. doi:10.1007/s12105-009-0126-1. PMC 2811624. PMID 20596971. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811624/.