Difference between revisions of "Human papillomavirus-associated head and neck squamous cell carcinoma"

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#redirect [[Head_and_neck_pathology#Human_papillomavirus-associated_head_and_neck_squamous_cell_carcinoma]]
'''Human papillomavirus-associated head and neck squamous cell carcinoma''', abbreviated '''HPV-associated SCC''', is a type of [[head and neck squamous cell carcinoma]].
 
It has a unique epidemiology, when compared to conventional head and neck [[squamous cell carcinoma]].
 
==General==
*Tumours associated with high risk HPV, typically [[HPV]] 16.<ref name=pmid22001331 >{{Cite journal  | last1 = Wang | first1 = XI. | last2 = Thomas | first2 = J. | last3 = Zhang | first3 = S. | title = Changing trends in human papillomavirus-associated head and neck squamous cell carcinoma. | journal = Ann Diagn Pathol | volume = 16 | issue = 1 | pages = 7-12 | month = Jan | year = 2012 | doi = 10.1016/j.anndiagpath.2011.07.003 | PMID = 22001331 }}</ref>
**Thought to be different that tumours driven by [[alcohol]] and [[smoking|tobacco]] use.<ref name=pmid21769577>{{Cite journal  | last1 = Wittekindt | first1 = C. | last2 = Wagner | first2 = S. | last3 = Klussmann | first3 = JP. | title = [HPV-associated head and neck cancer. The basics of molecular and translational research]. | journal = HNO | volume = 59 | issue = 9 | pages = 885-92 | month = Sep | year = 2011 | doi = 10.1007/s00106-011-2357-1 | PMID = 21769577 }}</ref>
***Patients tend to be male and slightly younger - risk thought to be due to sexual practices.<ref name=pmid22046680>{{Cite journal  | last1 = Vourexakis | first1 = Z. | last2 = Dulguerov | first2 = P. | title = [HPV associated head and neck cancers]. | journal = Rev Med Suisse | volume = 7 | issue = 311 | pages = 1919-22 | month = Oct | year = 2011 | doi =  | PMID = 22046680 }}</ref>
*Lesions more radiosensitive and usually have a better prognosis.<ref name=pmid22001331/>
 
==Gross==
Classic locations:
*Tonsil and base of tongue<ref name=pmid21752613/> (palatine tonsil, lingual tonsil, oropharynx).
 
Note:
*Memory device:
**Where the tip of the [[penis]] goes when someone is ''deep throating''.
 
==Microscopic==
Features:<ref name=pmid20596971>{{Cite journal  | last1 = Chernock | first1 = RD. | last2 = El-Mofty | first2 = SK. | last3 = Thorstad | first3 = WL. | last4 = Parvin | first4 = CA. | last5 = Lewis | first5 = JS. | title = HPV-related nonkeratinizing squamous cell carcinoma of the oropharynx: utility of microscopic features in predicting patient outcome. | journal = Head Neck Pathol | volume = 3 | issue = 3 | pages = 186-94 | month = Sep | year = 2009 | doi = 10.1007/s12105-009-0126-1 | PMID = 20596971 | PMC = 2811624 | URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811624/?tool=pubmed }}</ref>
*Typically non-keratinizing squamous cell carcinoma.
 
DDx:
*HPV-negative squamous cell carcinoma - see ''[[squamous cell carcinoma of the head and neck]]''.
*[[Nasopharyngeal carcinoma]].
 
Images:
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811624/figure/Fig1/ HPV NK SCC (nih.gov)].
 
==IHC==
*p16 +ve.<ref name=pmid21752613>{{Cite journal  | last1 = Heath | first1 = S. | last2 = Willis | first2 = V. | last3 = Allan | first3 = K. | last4 = Purdie | first4 = K. | last5 = Harwood | first5 = C. | last6 = Shields | first6 = P. | last7 = Simcock | first7 = R. | last8 = Williams | first8 = T. | last9 = Gilbert | first9 = DC. | title = Clinically significant human papilloma virus in squamous cell carcinoma of the head and neck in UK practice. | journal = Clin Oncol (R Coll Radiol) | volume = 24 | issue = 1 | pages = e18-23 | month = Feb | year = 2012 | doi = 10.1016/j.clon.2011.05.007 | PMID = 21752613 }}</ref>
*EBER -ve.
 
==See also==
*[[Head and neck pathology]].
*[[Squamous cell carcinoma]].
*[[Nasopharyngeal carcinoma]].
*[[Squamous cell carcinoma of the head and neck]].
 
==References==
{{Reflist|2}}


[[Category:Diagnosis]]
[[Category:Diagnosis]]
[[Category:Head and neck pathology]]

Revision as of 01:04, 26 February 2014

Human papillomavirus-associated head and neck squamous cell carcinoma, abbreviated HPV-associated SCC, is a type of head and neck squamous cell carcinoma.

It has a unique epidemiology, when compared to conventional head and neck squamous cell carcinoma.

General

  • Tumours associated with high risk HPV, typically HPV 16.[1]
    • Thought to be different that tumours driven by alcohol and tobacco use.[2]
      • Patients tend to be male and slightly younger - risk thought to be due to sexual practices.[3]
  • Lesions more radiosensitive and usually have a better prognosis.[1]

Gross

Classic locations:

  • Tonsil and base of tongue[4] (palatine tonsil, lingual tonsil, oropharynx).

Note:

  • Memory device:
    • Where the tip of the penis goes when someone is deep throating.

Microscopic

Features:[5]

  • Typically non-keratinizing squamous cell carcinoma.

DDx:

Images:

IHC

  • p16 +ve.[4]
  • EBER -ve.

See also

References

  1. ↑ 1.0 1.1 Wang, XI.; Thomas, J.; Zhang, S. (Jan 2012). "Changing trends in human papillomavirus-associated head and neck squamous cell carcinoma.". Ann Diagn Pathol 16 (1): 7-12. doi:10.1016/j.anndiagpath.2011.07.003. PMID 22001331.
  2. ↑ Wittekindt, C.; Wagner, S.; Klussmann, JP. (Sep 2011). "[HPV-associated head and neck cancer. The basics of molecular and translational research].". HNO 59 (9): 885-92. doi:10.1007/s00106-011-2357-1. PMID 21769577.
  3. ↑ Vourexakis, Z.; Dulguerov, P. (Oct 2011). "[HPV associated head and neck cancers].". Rev Med Suisse 7 (311): 1919-22. PMID 22046680.
  4. ↑ 4.0 4.1 Heath, S.; Willis, V.; Allan, K.; Purdie, K.; Harwood, C.; Shields, P.; Simcock, R.; Williams, T. et al. (Feb 2012). "Clinically significant human papilloma virus in squamous cell carcinoma of the head and neck in UK practice.". Clin Oncol (R Coll Radiol) 24 (1): e18-23. doi:10.1016/j.clon.2011.05.007. PMID 21752613.
  5. ↑ Chernock, RD.; El-Mofty, SK.; Thorstad, WL.; Parvin, CA.; Lewis, JS. (Sep 2009). "HPV-related nonkeratinizing squamous cell carcinoma of the oropharynx: utility of microscopic features in predicting patient outcome.". Head Neck Pathol 3 (3): 186-94. doi:10.1007/s12105-009-0126-1. PMC 2811624. PMID 20596971. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811624/.
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