Histology artifacts

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Histology artifacts are common.

Cautery artifact

Tissue fold

  • Darker well demarcated line with apparent disruption of the architecture.

Images

Chatter artifact

  • Fine parallel lines.

Images

Tissue tearing

  • Usually due to something intrinsic to the tissue that is hard, e.g. calcium.

Image

Sponge artifact

  • Angulated pieces of tissue with punched-out missing fragments.[1]
  • May result in little squares of tissue arranged in a regular pattern.

Images

Bubble artifact

Large

  • Large bubbles of air under the cover slip.

Images

Coverslip artifact

Features:

  • Black-grey lines - takes on the outline of the tissue beneath it.
  • Above the plane-of-focus of the tissue - key feature.

Images

Case 1

See also

References

  1. Landas SK, Bromley CM (December 1990). "Sponge artifact in biopsy specimens". Arch. Pathol. Lab. Med. 114 (12): 1285–7. PMID 2252429.

External links