Eosinophilic vacuolated tumour

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High-grade oncocytic renal tumour, abbreviated HOT, is a kidney tumour type currently not recognized by the WHO classification as per the 2016 Blue Book.

General

Microscopic

Features:[1]

  • Abundant oncocytic cytoplasm with prominent intracytoplasmic vacuoles.
  • Round nuclei
  • Prominent nucleoli (ISUP nucleolar grade 3).
  • No perinuclear halos.

DDx:

Images

IHC

Features:[1]

  • PAX8 +ve (13 of 13 cases).
  • AE1/AE3 +ve.
  • CK18 +ve.
  • SDHB +ve.
  • CD10 +ve (12 of 13 cases).
  • HMB45 -ve.
  • Melan A -ve.
  • TFE3 -ve.

See also

References

  1. 1.0 1.1 He, H.; Trpkov, K.; Martinek, P.; Isikci, OT.; Maggi-Galuzzi, C.; Alaghehbandan, R.; Gill, AJ.; Tretiakova, M. et al. (Dec 2018). ""High-grade oncocytic renal tumor": morphologic, immunohistochemical, and molecular genetic study of 14 cases.". Virchows Arch 473 (6): 725-738. doi:10.1007/s00428-018-2456-4. PMID 30232607.