Difference between revisions of "Eosinophilic vacuolated tumour"
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*Previously lumped into ''[[renal hybrid oncocytic/chromophobe tumour]]''. | *Previously lumped into ''[[renal hybrid oncocytic/chromophobe tumour]]''. | ||
*Evolving entity. | *Evolving entity. | ||
*May be seen within the context of [[tuberous sclerosis]].<ref name=pmid31002177>{{Cite journal | last1 = Trpkov | first1 = K. | last2 = Bonert | first2 = M. | last3 = Gao | first3 = Y. | last4 = Kapoor | first4 = A. | last5 = He | first5 = H. | last6 = Yilmaz | first6 = A. | last7 = Gill | first7 = AJ. | last8 = Williamson | first8 = SR. | last9 = Comperat | first9 = E. | title = High-grade oncocytic tumour (HOT) of kidney in a patient with tuberous sclerosis complex. | journal = Histopathology | volume = | issue = | pages = | month = Apr | year = 2019 | doi = 10.1111/his.13876 | PMID = 31002177 }}</ref> | |||
==Microscopic== | ==Microscopic== | ||
Revision as of 21:11, 14 July 2019
High-grade oncocytic renal tumour, abbreviated HOT, is a kidney tumour type currently not recognized by the WHO classification as per the 2016 Blue Book.
General
- Previously lumped into renal hybrid oncocytic/chromophobe tumour.
- Evolving entity.
- May be seen within the context of tuberous sclerosis.[1]
Microscopic
Features:[2]
- Abundant oncocytic cytoplasm with prominent intracytoplasmic vacuoles.
- Round nuclei
- No "raisinoid" nuclei typical of chromophobe RCC.
- Prominent nucleoli (ISUP nucleolar grade 3).
- No perinuclear halos.
DDx:
- Renal oncocytoma.
- Renal hybrid oncocytic/chromophobe tumour.
- Chromophobe renal cell carcinoma.
- Other renal tumours with eosinophilic cytoplasm.
Images
HOT - low mag. (WC)
HOT - intermed. mag. (WC)
HOT - intermed. mag. (WC)
HOT - high mag. (WC)
HOT - high mag. (WC)
HOT - very high mag. (WC)
IHC
Features:[2]
- PAX8 +ve (13 of 13 cases).
- AE1/AE3 +ve.
- CK18 +ve.
- SDHB +ve.
- CD10 +ve (12 of 13 cases).
- HMB45 -ve.
- Melan A -ve.
- TFE3 -ve.
See also
References
- ↑ Trpkov, K.; Bonert, M.; Gao, Y.; Kapoor, A.; He, H.; Yilmaz, A.; Gill, AJ.; Williamson, SR. et al. (Apr 2019). "High-grade oncocytic tumour (HOT) of kidney in a patient with tuberous sclerosis complex.". Histopathology. doi:10.1111/his.13876. PMID 31002177.
- ↑ 2.0 2.1 He, H.; Trpkov, K.; Martinek, P.; Isikci, OT.; Maggi-Galuzzi, C.; Alaghehbandan, R.; Gill, AJ.; Tretiakova, M. et al. (Dec 2018). ""High-grade oncocytic renal tumor": morphologic, immunohistochemical, and molecular genetic study of 14 cases.". Virchows Arch 473 (6): 725-738. doi:10.1007/s00428-018-2456-4. PMID 30232607.