Hibernoma

From Libre Pathology
Jump to navigation Jump to search
The printable version is no longer supported and may have rendering errors. Please update your browser bookmarks and please use the default browser print function instead.
Hibernoma
Diagnosis in short

Hibernoma. H&E stain.

LM large polygonal/oval cells with central & small nucleus; nucleoli typically prominent; cytoplasm multivacuolated, oval, eosinophilic, granular
LM DDx reaction to silicone implant
Gross lobulated lesion, light-brown, usually extremities
Site soft tissue - adipocytic lesions

Clinical history young adults
Prevalence uncommon
Prognosis benign
Clin. DDx Lipoma

Hibernoma, also tumour of brown fat,[1] is an uncommon adipocytic tumour.

General

  • Consists of brown fat (present in the infants to generate heat).[2]
  • Benign.
  • Usually asymptomatic.[3]

Epidemiology:

  • Young adults.

Gross

  • Well-circumscribed.
  • Lobulated and light-brown on sectioning.

Microscopic

Features:[4]

  • Large polygonal/oval cells:
    • Nucleus - central & small.[5]
      • Nucleoli typically prominent.[6]
    • Cytoplasm - multivacuolated, oval, eosinophilic, granular.
  • +/-Prominent blood vessels, central.[7]

DDx:

  • Reaction to silicone implant.

Images

See also

References

  1. SHUTE, D. (Nov 1954). "Tumours of brown fat.". Can Med Assoc J 71 (5): 484-5. PMID 13209434.
  2. Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 605. ISBN 978-0781765275.
  3. Ahmed SA, Schuller I (December 2008). "Pediatric hibernoma: a case review". J. Pediatr. Hematol. Oncol. 30 (12): 900–1. doi:10.1097/MPH.0b013e318184e6dd. PMID 19131775.
  4. Chen DY, Wang CM, Chan HL (March 1998). "Hibernoma. Case report and literature review". Dermatol Surg 24 (3): 393–5. PMID 9537018.
  5. http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675(06)70271-6
  6. http://surgpathcriteria.stanford.edu/softfat/hibernoma/
  7. URL: http://radiographics.rsna.org/content/24/5/1433.full. Accessed on: 11 February 2013.