Hereditary diffuse gastric cancer

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Signet ring cell carcinoma, as may be seen in hereditary diffuse gastric cancer. H&E stain.

Hereditary diffuse gastric cancer, abbreviated HDGC, is an important hereditary cause of diffuse gastric cancer.^[1]

It is caused by mutations in the epithelial cadherin gene (also E-cadherin and CDH1).^[2]^[3]

General

It is associated with:

References

↑ Sereno M, Aguayo C, Guillén Ponce C, et al. (September 2011). "Gastric tumours in hereditary cancer syndromes: clinical features, molecular biology and strategies for prevention". Clin Transl Oncol 13 (9): 599–610. PMID 21865131.
↑ Online 'Mendelian Inheritance in Man' (OMIM) 137215
↑ Online 'Mendelian Inheritance in Man' (OMIM) 192090

[1] Sereno M, Aguayo C, Guillén Ponce C, et al. (September 2011). "Gastric tumours in hereditary cancer syndromes: clinical features, molecular biology and strategies for prevention". Clin Transl Oncol 13 (9): 599–610. PMID 21865131.

[omim137215-2] Online 'Mendelian Inheritance in Man' (OMIM) 137215

[3] Online 'Mendelian Inheritance in Man' (OMIM) 192090

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[2]

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Hereditary diffuse gastric cancer

General

See also

References

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