Granulomatous appendicitis

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Granulomatous appendicitis is an inflammatory process involving the vermiform appendix characterized by granulomas.

Interval appendectomy redirects to this article, as granulomas are often seen in that context.


Most common cause:

  • Yersinia appendicitis.[1]


  • Yersinia appendicitis.[1]
    • Yersinia = gram negative rod (red on Gram stain).
    • "Safety pin"-like appearance[3] - approximately 0.5 micrometers diameter x 2 micrometers length.
  • Other micro-organism (TB, fungus).
  • Crohn's disease.
  • Sarcoidosis.
  • Foreign body reaction.
  • Interval (delayed) appendectomy.
    • Approximately 60% of delayed appendectomies have granulomas.[4]



  • Granulomas.
  • +/-"Safety pin"-like organisms (Yersinia).


See also


  1. 1.0 1.1 Lamps LW, Madhusudhan KT, Greenson JK, et al. (April 2001). "The role of Yersinia enterocolitica and Yersinia pseudotuberculosis in granulomatous appendicitis: a histologic and molecular study". Am. J. Surg. Pathol. 25 (4): 508–15. PMID 11257626.
  3. URL: Accessed on: 30 June 2011.
  4. Guo, G.; Greenson, JK. (Aug 2003). "Histopathology of interval (delayed) appendectomy specimens: strong association with granulomatous and xanthogranulomatous appendicitis.". Am J Surg Pathol 27 (8): 1147-51. PMID 12883248.