Difference between revisions of "Gonadoblastoma"

From Libre Pathology
Jump to navigation Jump to search
(split out)
(tweka)
Line 4: Line 4:
| Width      =  
| Width      =  
| Caption    = Gondaloblastoma. [[H&E stain]].
| Caption    = Gondaloblastoma. [[H&E stain]].
| Micro      = immature germ cells (resembling Sertoli cells or granulosa cells), primitive germ cells resemble those of a [[dysgerminoma]],  
| Micro      = immature germ cells (resembling Sertoli cells or granulosa cells),{{fact}} primitive germ cells resemble those of a [[dysgerminoma]], +/-calcification (very common), +/-eosinophilic basement membrane material between the (primitive) germ cells and support cells.
+/-calcification (very common), +/-eosinophilic basement membrane material between the (primitive) germ cells and support cells.
| Subtypes  =
| Subtypes  =
| LMDDx      = [[dysgerminoma]]
| LMDDx      = [[dysgerminoma]]
Line 41: Line 40:
==Microscopic==
==Microscopic==
Features:<ref name=Ref_PBoD1104>{{Ref PBoD|1104}}</ref>
Features:<ref name=Ref_PBoD1104>{{Ref PBoD|1104}}</ref>
*Immature germ cells resembling Sertoli cells or granulosa cells.
*Immature germ cells resembling Sertoli cells or granulosa cells.{{fact}}
**Sertoli cells = moderate cytoplasm in a trabecular or tubular architecture.
**Sertoli cells = moderate cytoplasm in a trabecular or tubular architecture.
**Granulosa cells = form follicle-like structures.
**Granulosa cells = form follicle-like structures.

Revision as of 23:30, 13 July 2013

Gonadoblastoma
Diagnosis in short

Gondaloblastoma. H&E stain.

LM immature germ cells (resembling Sertoli cells or granulosa cells),[citation needed] primitive germ cells resemble those of a dysgerminoma, +/-calcification (very common), +/-eosinophilic basement membrane material between the (primitive) germ cells and support cells.
LM DDx dysgerminoma
Site ovary

Gonadoblastoma is a rare germ cell tumour with sex cord elements.

General

  • Associated with abnormal sexual development.
  • Often coexist with a dysgerminoma.
  • A mixed tumour that consists of (1) primitive germ cells and (2) sex cord elements.

Gross

  • +/-Cystic.

Microscopic

Features:[1]

  • Immature germ cells resembling Sertoli cells or granulosa cells.[citation needed]
    • Sertoli cells = moderate cytoplasm in a trabecular or tubular architecture.
    • Granulosa cells = form follicle-like structures.
      • May form nests.
  • Primitive germ cells resemble those of a dysgerminoma.
    • Polygonal cells with a central nucleus, squared-off nuclear membrane and clear cytoplasm.
  • +/-Calcification (very common).
  • +/-Eosinophilic basement membrane material between the (primitive) germ cells and support cells.[2]

Images

www:

See also

References

  1. Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, Mo: Elsevier Saunders. pp. 1104. ISBN 0-7216-0187-1.
  2. URL: http://www.flickr.com/photos/ckrishnan/3972432044/in/photostream/. Accessed on: 11 September 2011.