Difference between revisions of "Gonadoblastoma"

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#redirect [[Germ_cell_tumours#Gonadoblastoma]]
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Gonadoblastoma_-_b_-_high_mag.jpg
| Width      =
| Caption    = Gondaloblastoma. [[H&E stain]].
| Micro      = immature germ cells (resembling Sertoli cells or granulosa cells), primitive germ cells resemble those of a [[dysgerminoma]],
+/-calcification (very common), +/-eosinophilic basement membrane material between the (primitive) germ cells and support cells.
| Subtypes  =
| LMDDx      = [[dysgerminoma]]
| Stains    =
| IHC        =
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Site      = [[ovary]]
| Assdx      =
| Syndromes  =
| Clinicalhx =
| Signs      =
| Symptoms  =
| Prevalence =
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  =
| Other      =
| ClinDDx    =
}}
'''Gonadoblastoma''' is a rare [[germ cell tumour]] with sex cord elements.
 
==General==
*Associated with abnormal sexual development.
*Often coexist with a [[dysgerminoma]].
*A mixed tumour that consists of (1) primitive germ cells and (2) sex cord elements.
 
==Gross==
*+/-Cystic.
 
==Microscopic==
Features:<ref name=Ref_PBoD1104>{{Ref PBoD|1104}}</ref>
*Immature germ cells resembling Sertoli cells or granulosa cells.
**Sertoli cells = moderate cytoplasm in a trabecular or tubular architecture.
**Granulosa cells = form follicle-like structures.
***May form nests.
*Primitive germ cells resemble those of a [[dysgerminoma]].
**Polygonal cells with a central nucleus, squared-off nuclear membrane and clear cytoplasm.
*+/-Calcification (very common).
*+/-Eosinophilic basement membrane material between the (primitive) germ cells and support cells.<ref>URL: [http://www.flickr.com/photos/ckrishnan/3972432044/in/photostream/ http://www.flickr.com/photos/ckrishnan/3972432044/in/photostream/]. Accessed on: 11 September 2011.</ref>
 
===Images===
<gallery>
Image:Gonadoblastoma_-_intermed_mag.jpg | Gonadoblastoma - intermed. mag. (WC/Nephron)
Image:Gonadoblastoma_-_b_-_high_mag.jpg | Gonadoblastoma - high mag. (WC/Nephron)
</gallery>
www:
*[http://www.webpathology.com/image.asp?n=40&Case=532 Gonadoblastoma - low mag. (webpathology.com)].
*[http://www.webpathology.com/image.asp?case=532&n=42 Gonadoblastoma - high mag. (webpathology.com)].
*[http://www.webpathology.com/image.asp?case=532&n=44 Gonadoblastoma - high mag. (webpathology.com)].
*[http://www.flickr.com/photos/ckrishnan/3972431774/in/photostream/ Gonadoblastoma - low mag. (flickr.com)].
*[http://www.flickr.com/photos/ckrishnan/3972432404/in/photostream/ Gonadoblastoma - intermed. mag. (flickr.com)].
*[http://www.flickr.com/photos/ckrishnan/3972432044/in/photostream/ Gonadoblastoma - high mag. (flickr.com)].
*[http://path.upmc.edu/cases/case356.html Gonadoblastoma - several cases (upmc.edu)].
 
==See also==
*[[Germ cell tumours]].
 
==References==
{{Reflist|2}}


[[Category:Diagnosis]]
[[Category:Diagnosis]]

Revision as of 23:30, 13 July 2013

Gonadoblastoma
Diagnosis in short

Gondaloblastoma. H&E stain.
LM

immature germ cells (resembling Sertoli cells or granulosa cells), primitive germ cells resemble those of a dysgerminoma,

+/-calcification (very common), +/-eosinophilic basement membrane material between the (primitive) germ cells and support cells.
LM DDx dysgerminoma
Site ovary

Gonadoblastoma is a rare germ cell tumour with sex cord elements.

General

  • Associated with abnormal sexual development.
  • Often coexist with a dysgerminoma.
  • A mixed tumour that consists of (1) primitive germ cells and (2) sex cord elements.

Gross

  • +/-Cystic.

Microscopic

Features:[1]

  • Immature germ cells resembling Sertoli cells or granulosa cells.
    • Sertoli cells = moderate cytoplasm in a trabecular or tubular architecture.
    • Granulosa cells = form follicle-like structures.
      • May form nests.
  • Primitive germ cells resemble those of a dysgerminoma.
    • Polygonal cells with a central nucleus, squared-off nuclear membrane and clear cytoplasm.
  • +/-Calcification (very common).
  • +/-Eosinophilic basement membrane material between the (primitive) germ cells and support cells.[2]

Images

  • Gonadoblastoma - intermed. mag. (WC/Nephron)

  • Gonadoblastoma - high mag. (WC/Nephron)

www:

See also

References

  1. ↑ Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, Mo: Elsevier Saunders. pp. 1104. ISBN 0-7216-0187-1.
  2. ↑ URL: http://www.flickr.com/photos/ckrishnan/3972432044/in/photostream/. Accessed on: 11 September 2011.
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