Difference between revisions of "Glassy cell carcinoma"

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#redirect [[Uterine_cervix#Glassy_cell_carcinoma]]
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'''Glassy cell carcinoma''', abbreviated '''GCC''', is a rare [[malignancy]] of the [[uterine cervix]].
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==General==
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*Rare.
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*Rapid growth, poor prognosis.<ref name=pmid19527406>{{Cite journal  | last1 = Nasu | first1 = K. | last2 = Takai | first2 = N. | last3 = Narahara | first3 = H. | title = Multimodal treatment for glassy cell carcinoma of the uterine cervix. | journal = J Obstet Gynaecol Res | volume = 35 | issue = 3 | pages = 584-7 | month = Jun | year = 2009 | doi = 10.1111/j.1447-0756.2008.00968.x | PMID = 19527406 }}</ref>
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*Considered a subtype of [[adenosquamous carcinoma]].<ref name=pmid22384631>{{Cite journal  | last1 = Kosińiska-Kaczyńska | first1 = K. | last2 = Mazanowska | first2 = N. | last3 = Bomba-Opoń | first3 = D. | last4 = Horosz | first4 = E. | last5 = Marczewska | first5 = M. | last6 = Wielgoś | first6 = M. | title = Glassy cell carcinoma of the cervix--a case report with review of the literature. | journal = Ginekol Pol | volume = 82 | issue = 12 | pages = 936-9 | month = Dec | year = 2011 | doi =  | PMID = 22384631 }}</ref>
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==Microscopic==
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Features:<ref name=pmid11393075>{{Cite journal  | last1 = Reis-Filho | first1 = JS. | last2 = Fillus Neto | first2 = J. | last3 = Schonemann | first3 = E. | last4 = Sanderson | first4 = A. | last5 = Schmitt | first5 = FC. | title = Glassy cell carcinoma of the uterine cervix. Report of a case with cytohistologic and immunohistochemical study. | journal = Acta Cytol | volume = 45 | issue = 3 | pages = 407-10 | month =  | year =  | doi =  | PMID = 11393075 }}</ref>
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*Epithelioid cells in sheets or cords.
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*Round/oval nucleus.
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*One or more prominent nucleoli.
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*Abundant finely vacuolated eosinophilic to amphophilic cytoplasm.
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*Distinct cell borders.
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*Inflammation - esp. eosinophils.<ref>URL: [http://www.webpathology.com/image.asp?n=2&Case=561 http://www.webpathology.com/image.asp?n=2&Case=561]. Accessed on: 4 September 2011.</ref>
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DDx:
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*[[Adenosquamous carcinoma of the uterine cervix]].
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*[[Squamous carcinoma of the uterine cervix]].
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===Images===
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<gallery>
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Image:Glassy_cell_carcinoma_-_low_mag.jpg | GCC - low mag. (WC)
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Image:Glassy_cell_carcinoma_-_intermed_mag.jpg | GCC - intermed. mag. (WC)
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Image:Glassy_cell_carcinoma_-_high_mag.jpg | GCC - high mag. (WC)
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Image:Glassy_cell_carcinoma_-_very_high_mag.jpg | GCC - very high mag. (WC)
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</gallery>
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www:
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*[http://www.webpathology.com/image.asp?n=1&Case=561 GCC - low mag. (webpathology.com)].
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*[http://www.webpathology.com/image.asp?n=2&Case=561 GCC - high mag. (webpathology.com)].
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*[http://path.upmc.edu/cases/case100/dx.html GCC - several images (upmc.edu)].
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==Stains==
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*[[PAS stain]] - marks plasma membrane.<ref name=pmid15318016>{{Cite journal  | last1 = Deshpande | first1 = AH. | last2 = Kotwal | first2 = MN. | last3 = Bobhate | first3 = SK. | title = Glassy cell carcinoma of the uterine cervix a rare histology. Report of three cases with a review of the literature. | journal = Indian J Cancer | volume = 41 | issue = 2 | pages = 92-5 | month =  | year =  | doi =  | PMID = 15318016 | URL = http://www.indianjcancer.com/text.asp?2004/41/2/92/12353}}</ref>
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==See also==
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*[[Eosinophils]].
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*[[Uterine cervix]].
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==References==
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{{Reflist|2}}
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[[Category:Diagnosis]]
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[[Category:Uterine cervix]]

Revision as of 02:24, 25 April 2014

Glassy cell carcinoma, abbreviated GCC, is a rare malignancy of the uterine cervix.

General

Microscopic

Features:[3]

  • Epithelioid cells in sheets or cords.
  • Round/oval nucleus.
  • One or more prominent nucleoli.
  • Abundant finely vacuolated eosinophilic to amphophilic cytoplasm.
  • Distinct cell borders.
  • Inflammation - esp. eosinophils.[4]

DDx:

Images

www:

Stains

See also

References

  1. Nasu, K.; Takai, N.; Narahara, H. (Jun 2009). "Multimodal treatment for glassy cell carcinoma of the uterine cervix.". J Obstet Gynaecol Res 35 (3): 584-7. doi:10.1111/j.1447-0756.2008.00968.x. PMID 19527406.
  2. Kosińiska-Kaczyńska, K.; Mazanowska, N.; Bomba-Opoń, D.; Horosz, E.; Marczewska, M.; Wielgoś, M. (Dec 2011). "Glassy cell carcinoma of the cervix--a case report with review of the literature.". Ginekol Pol 82 (12): 936-9. PMID 22384631.
  3. Reis-Filho, JS.; Fillus Neto, J.; Schonemann, E.; Sanderson, A.; Schmitt, FC.. "Glassy cell carcinoma of the uterine cervix. Report of a case with cytohistologic and immunohistochemical study.". Acta Cytol 45 (3): 407-10. PMID 11393075.
  4. URL: http://www.webpathology.com/image.asp?n=2&Case=561. Accessed on: 4 September 2011.
  5. Deshpande, AH.; Kotwal, MN.; Bobhate, SK.. "Glassy cell carcinoma of the uterine cervix a rare histology. Report of three cases with a review of the literature.". Indian J Cancer 41 (2): 92-5. PMID 15318016.