Difference between revisions of "Giant cells"

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Line 32: Line 32:
| Langhans giant cell  
| Langhans giant cell  
| peripheral eccentric nuclei<ref name=Ref_InstantPath7>{{Ref InstantPath|7}}</ref>
| peripheral eccentric nuclei<ref name=Ref_InstantPath7>{{Ref InstantPath|7}}</ref>
| suberculosis, sarcoidosis.
| tuberculosis, sarcoidosis.
| '''not''' to be confused with ''Langerhans cells''
| '''not''' to be confused with ''Langerhans cells''
| [[Image:Granulation_tissue_containg_a_poorly_formed_granuloma_with_a_Langhan%27s_giant_cell.jpg|thumb|200px|LGC (WC)]]
| [[Image:Granulation_tissue_containg_a_poorly_formed_granuloma_with_a_Langhan%27s_giant_cell.jpg|thumb|200px|LGC (WC)]]

Revision as of 11:57, 5 July 2018

Giant cell from a bronchial wash. Pap stain.

Giant cells are "big" cells with multiple nuclei. They come in different flavours, which are suggestive of causality.

This article deals with the classic types of giant cells. A more general differential diagnosis of giant cells is in giant cell lesions.

Giant cell types

List:

  • Touton giant cell.
  • Osteoclast-like giant cell.
  • Foreign body type giant cell.

Table

Type Histology DDx Other Image
Touton giant cell nuclei form a ring around the cell periphery juvenile xanthogranuloma, Erdheim-Chester disease high lipid content lesions[1]
JXG (WC)
Epithelioid type scattered nuclei[2] drug reaction, neoplasm, foreign body, infection, idiopathic, autoimmune, allergic granulomatous inflammation
Granuloma (WC)
Langhans giant cell peripheral eccentric nuclei[2] tuberculosis, sarcoidosis. not to be confused with Langerhans cells
LGC (WC)
Osteoclast-like giant cells round nuclei osteoclasts, others AKA osteoclast-type giant cells

See also

References

  1. URL: http://granuloma.homestead.com/giant_cells.html. Accessed on: 7 February 2011.
  2. 2.0 2.1 Borley, Neil R.; Warren, Bryan F. (2007). Instant Pathology (1st ed.). Wiley-Blackwell. pp. 7. ISBN 978-1405132909.