Giant cell lesions
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Giant cell lesions appear from time to time.
The DDx is large:[1]
- True neoplasms:
- Giant cell tumour of bone.
- Giant cell tumour of soft tissue (peripheral giant cell granuloma). (???)
- Giant cell tumour of the jaw (central giant cell granuloma). (???)
- Giant cell tumour of the tendon sheath.
- Undifferentiated pleomorphic sarcoma with giant cells.
- Osteosarcoma with giant cells.
- Aneurysmal bone cyst
- Giant cell reparative granuloma (AKA solid aneurysmal bone cyst[2]).
- Non-neoplastic:
- Granulomatous disease:
- Sarcoidosis.
- Other granulomatous disease.
- Foreign body giant cells.
- Other:
- Syncytiotrophoblasts:
- Choriocarcinoma.
- May be seen in seminoma/germinoma.[3][4]
- Malignant melanoma.
- "Giant cell cystitis".
- Others.
- Syncytiotrophoblasts:
See also
- Bone.
- Giant cells.
- GCT - an abbreviation used for giant cell tumour and other tumours.
- Nuclear pleomorphism.
References
- ↑ Salzer-Kuntschik M (1998). "[Differential diagnosis of giant cell tumor of bone]" (in German). Verh Dtsch Ges Pathol 82: 154–9. PMID 10095427.
- ↑ Pan, Z.; Sanger, WG.; Bridge, JA.; Hunter, WJ.; Siegal, GP.; Wei, S. (Jan 2012). "A novel t(6;13)(q15;q34) translocation in a giant cell reparative granuloma (solid aneurysmal bone cyst).". Hum Pathol. doi:10.1016/j.humpath.2011.10.003. PMID 22285042.
- ↑ Hedinger, C.; von Hochstetter, AR.; Egloff, B. (Jul 1979). "Seminoma with syncytiotrophoblastic giant cells. A special form of seminoma.". Virchows Arch A Pathol Anat Histol 383 (1): 59-67. PMID 157614.
- ↑ Drut, R.; Jones, MC. (1984). "Germinoma of the pineal body with syncytiotrophoblastic giant cells.". Pediatr Pathol 2 (1): 65-70. PMID 6542213.