Difference between revisions of "Gastric adenocarcinoma and proximal polyposis of the stomach"
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*Very rare. | *Very rare. | ||
*APC promotor IB mutations.<ref name=pmid30584346/> | *APC promotor IB mutations.<ref name=pmid30584346/> | ||
*Autosomal dominant inheritance.<ref name=pmid30584346/> | |||
==Criteria== | ==Criteria== | ||
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**Histology predominantly [[fundic gland polyp]]s - some with dysplasia or adenocarcinoma in background. | **Histology predominantly [[fundic gland polyp]]s - some with dysplasia or adenocarcinoma in background. | ||
*No colorectal or duodenal polyposis. | *No colorectal or duodenal polyposis. | ||
*Exclusion of other heritable polyposis syndrome involving the stomach, proton pump inhibitor (PPI) use. | |||
*Exclusion of other heritable polyposis syndrome involving the stomach, PPI use. | |||
==See also== | ==See also== | ||
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[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Syndromes]] | [[Category:Syndromes]] | ||
[[Category:Stomach]] | |||
Revision as of 16:49, 16 September 2019
Gastric adenocarcinoma and proximal polyposis of the stomach, abbreviated GAPPS, is a rare syndrome characterized by fundic gland polyps and gastric adenocarcinoma.[1][2]
General
Criteria
Features - all required:[1]
- Polyps of stomach - body and fundus only.
- >100 polyps in index case or >30 polyps in first degree relative.
- Histology predominantly fundic gland polyps - some with dysplasia or adenocarcinoma in background.
- No colorectal or duodenal polyposis.
- Exclusion of other heritable polyposis syndrome involving the stomach, proton pump inhibitor (PPI) use.
See also
References
- ↑ 1.0 1.1 1.2 1.3 Rudloff, U. (2018). "Gastric adenocarcinoma and proximal polyposis of the stomach: diagnosis and clinical perspectives.". Clin Exp Gastroenterol 11: 447-459. doi:10.2147/CEG.S163227. PMID 30584346.
- ↑ Worthley, DL.; Phillips, KD.; Wayte, N.; Schrader, KA.; Healey, S.; Kaurah, P.; Shulkes, A.; Grimpen, F. et al. (May 2012). "Gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS): a new autosomal dominant syndrome.". Gut 61 (5): 774-9. doi:10.1136/gutjnl-2011-300348. PMID 21813476.