GFAP
GLIAL FIBRILLARY ACIDIC PROTEIN, abbreviated GFAP,[1] was one of the first delevloped antibodies and is a common immunostain used in neuropathology. It's expression is associated with glial differentiation, especially with astrocytes.
Positive
- Astrocytes (upregulated in reactive astrocytes) [2]
- astrocytoma and glioblastoma[3]
- minigemistcytes in oligodendroglioma[4]
- ependymoma
- ocassionally in medulloblastoma, plexus apilloma, schwannoma[5]
Images
GFAP in astrocytes.
GFAP in ependymoma
GFAP in glioblastoma
GFAP in glioblastoma
GFAP in PXA
GFAP in astrocytoma
GFAP in SEGA
Negative
See[6]
- Meningioma
- Lymphoma
- Carcinoma
- Melanoma
- Chordoma
- Paraganglioma
See also
References
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 137780
- ↑ Anderson, MA.; Ao, Y.; Sofroniew, MV. (Apr 2014). "Heterogeneity of reactive astrocytes.". Neurosci Lett 565: 23-9. doi:10.1016/j.neulet.2013.12.030. PMID 24361547.
- ↑ Lolait, SJ.; Harmer, JH.; Auteri, G.; Pedersen, JS.; Toh, BH. (Oct 1983). "Expression of glial fibrillary acidic protein, actin, fibronectin and factor VIII antigen in human astrocytomas.". Pathology 15 (4): 373-8. PMID 6326028.
- ↑ Herpers, MJ.; Budka, H. (1984). "Glial fibrillary acidic protein (GFAP) in oligodendroglial tumors: gliofibrillary oligodendroglioma and transitional oligoastrocytoma as subtypes of oligodendroglioma.". Acta Neuropathol 64 (4): 265-72. PMID 6391068.
- ↑ Reifenberger, G.; Szymas, J.; Wechsler, W. (1987). "Differential expression of glial- and neuronal-associated antigens in human tumors of the central and peripheral nervous system.". Acta Neuropathol 74 (2): 105-23. PMID 3314309.
- ↑ Gottschalk, J.; Szymaś, J. (1987). "[Significance of immunohistochemistry for neuro-oncology. VI. Occurrence, localization and distribution of glial fibrillary acid protein (GFAP) in 820 tumors].". Zentralbl Allg Pathol 133 (4): 319-30. PMID 3425011.