Difference between revisions of "GATA3"

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==Positive==
==Positive==
*[[Urothelial carcinoma]].<ref name=pmid22982890>{{cite journal |author=Chang A, Amin A, Gabrielson E, ''et al.'' |title=Utility of GATA3 immunohistochemistry in differentiating urothelial carcinoma from prostate adenocarcinoma and squamous cell carcinomas of the uterine cervix, anus, and lung |journal=Am. J. Surg. Pathol. |volume=36 |issue=10 |pages=1472–6 |year=2012 |month=October |pmid=22982890 |pmc=3444740 |doi=10.1097/PAS.0b013e318260cde7 |url=}}</ref>
*[[Urothelial carcinoma]].<ref name=pmid22982890>{{cite journal |author=Chang A, Amin A, Gabrielson E, ''et al.'' |title=Utility of GATA3 immunohistochemistry in differentiating urothelial carcinoma from prostate adenocarcinoma and squamous cell carcinomas of the uterine cervix, anus, and lung |journal=Am. J. Surg. Pathol. |volume=36 |issue=10 |pages=1472–6 |year=2012 |month=October |pmid=22982890 |pmc=3444740 |doi=10.1097/PAS.0b013e318260cde7 |url=}}</ref>
*[[Lobular breast carcinoma]].<ref name=pmid24061521>{{Cite journal  | last1 = Ellis | first1 = CL. | last2 = Chang | first2 = AG. | last3 = Cimino-Mathews | first3 = A. | last4 = Argani | first4 = P. | last5 = Youssef | first5 = RF. | last6 = Kapur | first6 = P. | last7 = Montgomery | first7 = EA. | last8 = Epstein | first8 = JI. | title = GATA-3 immunohistochemistry in the differential diagnosis of adenocarcinoma of the urinary bladder. | journal = Am J Surg Pathol | volume = 37 | issue = 11 | pages = 1756-60 | month = Nov | year = 2013 | doi = 10.1097/PAS.0b013e31829cdba7 | PMID = 24061521 }}</ref>
*[[Invasive breast cancer|Breast carcinoma]] - more sensitive than [[GCDFP-15]].<ref name=pmid24145643>{{Cite journal  | last1 = Miettinen | first1 = M. | last2 = McCue | first2 = PA. | last3 = Sarlomo-Rikala | first3 = M. | last4 = Rys | first4 = J. | last5 = Czapiewski | first5 = P. | last6 = Wazny | first6 = K. | last7 = Langfort | first7 = R. | last8 = Waloszczyk | first8 = P. | last9 = Biernat | first9 = W. | title = GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumors. | journal = Am J Surg Pathol | volume = 38 | issue = 1 | pages = 13-22 | month = Jan | year = 2014 | doi = 10.1097/PAS.0b013e3182a0218f | PMID = 24145643 }}</ref>
**[[Lobular breast carcinoma]].<ref name=pmid24061521>{{Cite journal  | last1 = Ellis | first1 = CL. | last2 = Chang | first2 = AG. | last3 = Cimino-Mathews | first3 = A. | last4 = Argani | first4 = P. | last5 = Youssef | first5 = RF. | last6 = Kapur | first6 = P. | last7 = Montgomery | first7 = EA. | last8 = Epstein | first8 = JI. | title = GATA-3 immunohistochemistry in the differential diagnosis of adenocarcinoma of the urinary bladder. | journal = Am J Surg Pathol | volume = 37 | issue = 11 | pages = 1756-60 | month = Nov | year = 2013 | doi = 10.1097/PAS.0b013e31829cdba7 | PMID = 24061521 }}</ref>


===Images===
===Images===

Revision as of 14:25, 14 April 2016

GATA3
Immunostain in short

GATA3 staining in benign urothelium.
Use bladder versus prostate, bladder versus SCC
Subspeciality Genitourinary pathology
Normal staining pattern nuclear
Positive urothelial carcinoma, lobular breast carcinoma
Negative prostatic carcinoma, squamous cell carcinoma of the lung

GATA3 an immunostain that is increasingly used in genitourinary pathology.

Positive

Images

Negative

See also

References

  1. 1.0 1.1 1.2 Chang A, Amin A, Gabrielson E, et al. (October 2012). "Utility of GATA3 immunohistochemistry in differentiating urothelial carcinoma from prostate adenocarcinoma and squamous cell carcinomas of the uterine cervix, anus, and lung". Am. J. Surg. Pathol. 36 (10): 1472–6. doi:10.1097/PAS.0b013e318260cde7. PMC 3444740. PMID 22982890. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444740/.
  2. Miettinen, M.; McCue, PA.; Sarlomo-Rikala, M.; Rys, J.; Czapiewski, P.; Wazny, K.; Langfort, R.; Waloszczyk, P. et al. (Jan 2014). "GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumors.". Am J Surg Pathol 38 (1): 13-22. doi:10.1097/PAS.0b013e3182a0218f. PMID 24145643.
  3. Ellis, CL.; Chang, AG.; Cimino-Mathews, A.; Argani, P.; Youssef, RF.; Kapur, P.; Montgomery, EA.; Epstein, JI. (Nov 2013). "GATA-3 immunohistochemistry in the differential diagnosis of adenocarcinoma of the urinary bladder.". Am J Surg Pathol 37 (11): 1756-60. doi:10.1097/PAS.0b013e31829cdba7. PMID 24061521.