Difference between revisions of "Follicular dendritic cell sarcoma"

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'''Follicular dendritic cell sarcoma''', abbreviated '''FDCS''', is a very rare [[malignant]] tumour.
'''Follicular dendritic cell sarcoma''', abbreviated '''FDCS''', is a very rare [[malignant]] tumour.


It is also known as '''follicular dendritic cell tumour''' (abbreviated '''FDCT'''.<ref name=pmid17515347>{{Cite journal  | last1 = Leipsic | first1 = JA. | last2 = McAdams | first2 = HP. | last3 = Sporn | first3 = TA. | title = Follicular dendritic cell sarcoma of the mediastinum. | journal = AJR Am J Roentgenol | volume = 188 | issue = 6 | pages = W554-6 | month = Jun | year = 2007 | doi = 10.2214/AJR.04.1530 | PMID = 17515347 }}</ref>
It is also known as '''follicular dendritic cell tumour''' (abbreviated '''FDCT''').<ref name=pmid17515347>{{Cite journal  | last1 = Leipsic | first1 = JA. | last2 = McAdams | first2 = HP. | last3 = Sporn | first3 = TA. | title = Follicular dendritic cell sarcoma of the mediastinum. | journal = AJR Am J Roentgenol | volume = 188 | issue = 6 | pages = W554-6 | month = Jun | year = 2007 | doi = 10.2214/AJR.04.1530 | PMID = 17515347 }}</ref>


Other possible names are ''dendritic reticulum cell sarcoma'', (???) ''follicular dendritic cell neoplasm''. (???)
Other possible names are: ''dendritic reticulum cell sarcoma'', (???) ''follicular dendritic cell neoplasm''. (???)


==General==
==General==

Revision as of 12:00, 25 April 2014

Follicular dendritic cell sarcoma, abbreviated FDCS, is a very rare malignant tumour.

It is also known as follicular dendritic cell tumour (abbreviated FDCT).[1]

Other possible names are: dendritic reticulum cell sarcoma, (???) follicular dendritic cell neoplasm. (???)

General

  • Very rare.
  • Behave like a low-grade sarcoma.[2]
  • Reported association with Castleman disease (hyaline-vascular type).[2]

Microscopic

Features:[2]

  • Oval or spindle-shaped cellular & nuclear morphology.
  • Variable architecture (sheets, fascicles, whorles, storiform pattern).
  • Nuclei:
    • Small nucleoli.
    • Clear or dispersed chromatin.
  • Multinucleated cells.
  • Interspersed small lymphocytes - distinctive feature.
  • +/-Necrosis.
  • +/-Marked nuclear atypia.
  • +/-Abundant mitoses.

DDx:

Images

IHC

Features:[2]

  • CD21 +ve.
  • CD35 +ve.
  • Ki-M4p +ve
  • Ki-FDRC1p +ve.
  • Vimentin +ve.
  • S-100 +ve/-ve.
  • Muscle-specific actin +ve/-ve.
  • EMA +ve/-ve.

See also

References

  1. ↑ 1.0 1.1 Leipsic, JA.; McAdams, HP.; Sporn, TA. (Jun 2007). "Follicular dendritic cell sarcoma of the mediastinum.". AJR Am J Roentgenol 188 (6): W554-6. doi:10.2214/AJR.04.1530. PMID 17515347.
  2. ↑ 2.0 2.1 2.2 2.3 Perez-Ordoñez, B.; Rosai, J. (May 1998). "Follicular dendritic cell tumor: review of the entity.". Semin Diagn Pathol 15 (2): 144-54. PMID 9606805.
  3. ↑ Alexiev, BA.; Sailey, CJ.; McClure, SA.; Ord, RA.; Zhao, XF.; Papadimitriou, JC. (2007). "Primary histiocytic sarcoma arising in the head and neck with predominant spindle cell component.". Diagn Pathol 2: 7. doi:10.1186/1746-1596-2-7. PMID 17324277. http://www.diagnosticpathology.org/content/2/1/7.
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