Fibrous hamartoma of infancy

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Fibrous hamartoma of infancy is an uncommon lesion usually seen in infancy.

General

  • Uncommon.
  • Infants and young children.[1]

Gross

  • Typical location: lower back, gluteal region or scrotum.[2]

Microscopic

Features:[1]

  • Fibrous tissue.
  • Adipose tissue.
  • Mesenchymal tissue - nerve-like.
  • +/-Pseudoangiomatous pattern.

DDx:

Images

IHC

Features:[1]

  • S-100 -ve.
    • Adipose tissue +ve.
  • SMA +ve (fibrous tissue).
  • CD34 +ve (fibrous tissue, immature mesenchymal tissue, pseudoangiomatous foci).

See also

References

  1. 1.0 1.1 1.2 Saab, ST.; McClain, CM.; Coffin, CM. (Mar 2014). "Fibrous hamartoma of infancy: a clinicopathologic analysis of 60 cases.". Am J Surg Pathol 38 (3): 394-401. doi:10.1097/PAS.0000000000000104. PMID 24525510.
  2. 2.0 2.1 Kang, G.; Suh, YL.; Han, J.; Kwon, GY.; Lee, SK.; Seo, JM. (Jul 2011). "Fibrous hamartoma of infancy: an experience of a single institute.". J Korean Surg Soc 81 (1): 61-5. doi:10.4174/jkss.2011.81.1.61. PMID 22066102.
  3. F-Eire, P.; Fojon, JG. (Mar 2013). "Cutaneous changes in fibrous hamartoma of infancy.". Indian J Dermatol 58 (2): 160. doi:10.4103/0019-5154.108089. PMID 23716836.