Familial adenomatous polyposis

From Libre Pathology
Revision as of 19:44, 4 March 2011 by Michael (talk | contribs) (more)
Jump to navigation Jump to search

Familial adenomatous polyposis, abbreviated FAP and also known as familial polyposis coli, is a genetic condition that predisposes to adenomatous polyps and thus invariably results in colorectal cancer.

Inheritance

  • Autosomal dominant.

Gene

  • APC gene.

Variants

It comes in two flavours:

  1. FAP (no otherwise specified - the plain vanilla flavour).
    • Many polyps - typically > 100.
  2. Attenuated FAP, abbreviated AFAP.
    • Less polyps - typically 10 to 100.[1]
      • As one my think... they tend to get cancer later than (the plain vanilla) FAP.

Associations

Benign things:

Tumours:[1]

Benign tumours:[1]

Prevalence

1/11,300-37,600 in Europe.[1]

See also

References