Extranodal NK/T-cell lymphoma, nasal type

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Extranodal NK/T-cell lymphoma, nasal type (abbreviated ENKTCL), also known as extranodal natural kill lymphoma (abbreviated ENKL) and angiocentric lymphoma, is a rare type of lymphoma.

General

  • Common in east Asia.[1]
  • Strong association with EBV.
  • Poor prognosis.[2]

Microscopic

Features:

  • Atypical lymphoid cells:

Images:

IHC

Features:[3]

  • CD2 +ve.
  • CD3 +ve (cytoplasmic).
  • CD56 +ve.

Others:[4]

  • TIA-1 +ve.
  • CD7 +ve.
  • EBER +ve.

See also

References

  1. Suzuki, R.; Takeuchi, K.; Ohshima, K.; Nakamura, S. (Jun 2008). "Extranodal NK/T-cell lymphoma: diagnosis and treatment cues.". Hematol Oncol 26 (2): 66-72. doi:10.1002/hon.847. PMID 18283711.
  2. Tse, E.; Kwong, YL. (Jun 2013). "How I treat NK/T-cell lymphomas.". Blood 121 (25): 4997-5005. doi:10.1182/blood-2013-01-453233. PMID 23652805.
  3. Al-Hakeem, DA.; Fedele, S.; Carlos, R.; Porter, S. (Jan 2007). "Extranodal NK/T-cell lymphoma, nasal type.". Oral Oncol 43 (1): 4-14. doi:10.1016/j.oraloncology.2006.03.011. PMID 17064952.
  4. URL: http://path.upmc.edu/cases/case310.html. Accessed on: 14 January 2012.