Esophageal stricture
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Esophageal stricture is usually a clinical diagnosis. Considered broadly, strictures may be benign or malignant.
This article deals primarily with benign stricture of the esophagus or benign esophageal stricture.
General
Strictures in general:
- Malignant - it is the pathologist's job to help rule-out these.
- Benign.
- Most are distal.[1]
Treatment:
Microscopic
Features:
- Squamous mucosa with irritation:
- +/-Keratinization.
- Intraepithelial lymphocytes.
- Basal cell hyperplasia.
- Fibrosis (deep) - usually not seen.
DDx:
- GERD.
- Barrett's esophagus.
- Squamous cell carcinoma of the esophagus.
- Adenocarcinoma of the esophagus.
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ESOPHAGUS, BIOPSY: - SQUAMOUS MUCOSA WITH BASAL CELL HYPERPLASIA, MILD INTRAEPITHELIAL EDEMA, FOCAL EARLY KERATINIZATION AND INTRAEPITHELIAL LYMPHOCYTES. - SCANT COLUMNAR EPITHELIUM WITH MODERATE CHRONIC INACTIVE INFLAMMATION. - NEGATIVE FOR INTESTINAL METAPLASIA. - NEGATIVE FOR DYSPLASIA AND NEGATIVE FOR MALIGNANCY.
See also
References
- ↑ Kozarek, RA. (Dec 1984). "Proximal strictures of the esophagus.". J Clin Gastroenterol 6 (6): 505-11. PMID 6512226.
- ↑ Hourneaux de Moura, EG.; Toma, K.; Goh, KL.; Romero, R.; Dua, KS.; Felix, VN.; Levine, MS.; Kochhar, R. et al. (Oct 2013). "Stents for benign and malignant esophageal strictures.". Ann N Y Acad Sci 1300: 119-43. doi:10.1111/nyas.12242. PMID 24117639.
- ↑ Singhal, S.; Hasan, SS.; Cohen, DC.; Pfanner, T.; Reznik, S.; Duddempudi, S. (Sep 2013). "Multi-disciplinary approach for management of refractory benign occlusive esophageal strictures.". Therap Adv Gastroenterol 6 (5): 365-70. doi:10.1177/1756283X13492000. PMID 24003337.