Epstein-Barr virus-associated smooth muscle tumour
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Epstein-Barr virus-associated smooth muscle tumour, abbreviated EBV-SMT, is a very uncommon soft tissue lesion.[1]
General
- Immunosuppressed individuals, e.g. individuals with HIV.
- Caused by Epstein-Barr virus.
Microscopic
Features:[1]
- Smooth muscle lesion:
- Spindle cells in a fascicular arrangement.
- Usually minimal nuclear atypia and few mitoses.
- Lymphocytes.
DDx:
Image:
IHC
- SMA +ve
- Desmin +ve/-ve.
- CD34 -ve.
- CD117 -ve.
Image:
Molecular
References
- ↑ 1.0 1.1 Deyrup, AT.; Lee, VK.; Hill, CE.; Cheuk, W.; Toh, HC.; Kesavan, S.; Chan, EW.; Weiss, SW. (Jan 2006). "Epstein-Barr virus-associated smooth muscle tumors are distinctive mesenchymal tumors reflecting multiple infection events: a clinicopathologic and molecular analysis of 29 tumors from 19 patients.". Am J Surg Pathol 30 (1): 75-82. PMID 16330945.
- ↑ 2.0 2.1 Huang, J.; Loh, KS.; Petersson, F. (Dec 2010). "Epstein-barr virus-associated smooth muscle tumor of the larynx: report of a rare case mimicking leiomyosarcoma.". Head Neck Pathol 4 (4): 300-4. doi:10.1007/s12105-010-0201-7. PMID 20690046.