Difference between revisions of "Epstein-Barr virus"

From Libre Pathology
Jump to navigation Jump to search
(+image)
m (vauthors)
Line 42: Line 42:
==Molecular==
==Molecular==
*EBER +ve - [[in situ hybridization]] for RNA fragments in EBV.<ref name=pmid9761938>{{Cite journal  | last1 = Tornóczky | first1 = T. | last2 = Kelényi | first2 = G. | last3 = Pajor | first3 = L. | title = EBER oligonucleotide RNA in situ hybridization in EBV associated neoplasms. | journal = Pathol Oncol Res | volume = 4 | issue = 3 | pages = 201-5 | month =  | year = 1998 | doi =  | PMID = 9761938 }}</ref>
*EBER +ve - [[in situ hybridization]] for RNA fragments in EBV.<ref name=pmid9761938>{{Cite journal  | last1 = Tornóczky | first1 = T. | last2 = Kelényi | first2 = G. | last3 = Pajor | first3 = L. | title = EBER oligonucleotide RNA in situ hybridization in EBV associated neoplasms. | journal = Pathol Oncol Res | volume = 4 | issue = 3 | pages = 201-5 | month =  | year = 1998 | doi =  | PMID = 9761938 }}</ref>
**EBER = '''E'''pstein-'''B'''arr virus (EBV)-'''e'''ncoded small '''R'''NAs.<ref name=pmid20399962>{{cite journal |vauthors=Iwakiri D, Takada K |title=Role of EBERs in the pathogenesis of EBV infection |journal=Adv. Cancer Res. |volume=107 |issue= |pages=119–36 |date=2010 |pmid=20399962 |doi=10.1016/S0065-230X(10)07004-1 |url=}}</ref>
**EBER = '''E'''pstein-'''B'''arr virus (EBV)-'''e'''ncoded small '''R'''NAs.<ref name=pmid20399962>{{cite journal |authors=Iwakiri D, Takada K |title=Role of EBERs in the pathogenesis of EBV infection |journal=Adv. Cancer Res. |volume=107 |issue= |pages=119–36 |date=2010 |pmid=20399962 |doi=10.1016/S0065-230X(10)07004-1 |url=}}</ref>


==See also==
==See also==

Revision as of 20:28, 24 May 2020

Micrograph showing an EBER (Epstein-Barr virus (EBV)-encoded small RNAs) positive nasopharyngeal carcinoma. (WC)

The Epstein-Barr virus, abbreviated EBV, is virus implicated in several types of cancer.

General

Note:

  • The virus is Epstein... the tricuspid abnormality is Ebstein.

Associations

Cancer:[2]

Other:

Microscopic

Features:

  • Variable - see specific pathologies in Associations section.
    • +/-Atypical lymphocytes.
    • +/-Hemophagocytosis (uncommon).

Images:

IHC

  • Mixed population of CD3 & CD20 -- in benign.

Molecular

See also

References

  1. URL: http://www.meddean.luc.edu/lumen/MedEd/orfpath/herpes.htm. Accessed on: 14 April 2011.
  2. Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 169. ISBN 978-1416054542.
  3. McClain, KL.; Joshi, VV.; Murphy, SB. (Oct 1996). "Cancers in children with HIV infection.". Hematol Oncol Clin North Am 10 (5): 1189-201. PMID 8880205.
  4. Jin YK, Xie ZD, Yang S, Lu G, Shen KL (June 2010). "Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis: a retrospective study of 78 pediatric cases in mainland of China". Chin. Med. J. 123 (11): 1426–30. PMID 20819601.
  5. Deyrup, AT.; Lee, VK.; Hill, CE.; Cheuk, W.; Toh, HC.; Kesavan, S.; Chan, EW.; Weiss, SW. (Jan 2006). "Epstein-Barr virus-associated smooth muscle tumors are distinctive mesenchymal tumors reflecting multiple infection events: a clinicopathologic and molecular analysis of 29 tumors from 19 patients.". Am J Surg Pathol 30 (1): 75-82. PMID 16330945.
  6. Weinberg, I.; Neuman, T.; Margalit, M.; Ayman, F.; Wolf, DG.; Ben-Yehuda, A. (May 2009). "Epstein-barr virus-related diarrhea or exacerbation of inflammatory bowel disease: diagnostic dilemma.". J Clin Microbiol 47 (5): 1588-90. doi:10.1128/JCM.02477-08. PMID 19279175. http://jcm.asm.org/content/47/5/1588.full.
  7. Karlitz, JJ.; Li, ST.; Holman, RP.; Rice, MC. (Jan 2011). "EBV-associated colitis mimicking IBD in an immunocompetent individual.". Nat Rev Gastroenterol Hepatol 8 (1): 50-4. doi:10.1038/nrgastro.2010.192. PMID 21119609.
  8. Tornóczky, T.; Kelényi, G.; Pajor, L. (1998). "EBER oligonucleotide RNA in situ hybridization in EBV associated neoplasms.". Pathol Oncol Res 4 (3): 201-5. PMID 9761938.
  9. Iwakiri D, Takada K (2010). "Role of EBERs in the pathogenesis of EBV infection". Adv. Cancer Res. 107: 119–36. doi:10.1016/S0065-230X(10)07004-1. PMID 20399962.