Epithelial-myoepithelial carcinoma
Jump to navigation
Jump to search
The printable version is no longer supported and may have rendering errors. Please update your browser bookmarks and please use the default browser print function instead.
| Epithelial-myoepithelial carcinoma | |
|---|---|
| Diagnosis in short | |
 Epithelial-myoepithelial carcinoma. H&E stain. | |
|
| |
| LM | biphasic tumour with (1) epithelial layer, and (2) myoepithelial layer; variable architecture (solid, cystic, tubular, papillary); +/- spindle cells |
| LM DDx | adenoid cystic carcinoma (tubular variant), pleomorphic adenoma, tubular variant. |
| IHC | CAM5.2 +ve (epithelial comp.), p63 +ve (myoepithelial comp.) |
| Site | salivary gland - usually parotid gland |
|
| |
| Signs | salivary gland mass |
| Prevalence | very rare |
| Clin. DDx | other salivary gland masses |
Epithelial-myoepithelial carcinoma, abbreviated EMCa, is a rare malignant salivary gland tumour.
Should not be confused with myoepithelial carcinoma.
General
- Rare ~1% of salivary gland tumours.[1]
- Female:male = 1.5:1.[2]
- Usually older people - 50s or 60s.
- Usually parotid gland ~ 60% of cases.[2]
- Prognosis: usually good; 5-year and 10-year survival over 90% and 80% respectively.[2]
Notes:
- Most common malignant component in carcinoma ex pleomorphic adenoma.
- May be the same tumour as adenomyoepithelioma of the breast.[3]
- An analogous lung tumour exists - see epithelial-myoepithelial carcinoma of lung.[4]
Microscopic
Features:
- Biphasic tumour:[2]
- Epithelial layer.
- Myoepithelial layer - key feature.
- Architecture: variable (solid, cystic, tubular, papillary).
- +/-Spindle cells.
- Basement membrane-like material; may mimic adenoid cystic carcinoma.
Notes:
- Usually few mitoses.
DDx:
- Adenoid cystic carcinoma (tubular variant).
- Pleomorphic adenoma, tubular variant.
- Has focal epithelial-myoepithelial carcinoma-like areas.
Images
EMCa - intermed. mag. (WC/Nephron)
EMCa - high mag. (WC/Nephron)
EMCa - very high mag. (WC/Nephron)
www:
IHC
- CAM5.2 +ve -- epithelial component.
- p63 +ve -- myoepithelial component.
See also
References
- ↑ Tralongo, V.; Daniele, E.. "Epithelial-myoepithelial carcinoma of the salivary glands: a review of literature.". Anticancer Res 18 (1B): 603-8. PMID 9568184.
- ↑ 2.0 2.1 2.2 2.3 Seethala, RR.; Barnes, EL.; Hunt, JL. (Jan 2007). "Epithelial-myoepithelial carcinoma: a review of the clinicopathologic spectrum and immunophenotypic characteristics in 61 tumors of the salivary glands and upper aerodigestive tract.". Am J Surg Pathol 31 (1): 44-57. doi:10.1097/01.pas.0000213314.74423.d8. PMID 17197918.
- ↑ Seifert, G. (Sep 1998). "Are adenomyoepithelioma of the breast and epithelial-myoepithelial carcinoma of the salivary glands identical tumours?". Virchows Arch 433 (3): 285-8. PMID 9769134.
- ↑ Nakashima, Y.; Morita, R.; Ui, A.; Iihara, K.; Yazawa, T. (Jul 2018). "Epithelial-myoepithelial carcinoma of the lung: a case report.". Surg Case Rep 4 (1): 74. doi:10.1186/s40792-018-0482-8. PMID 29987577.
- ↑ [http://www.pathologyimagesinc.com/sgt-cytopath/epith-myoepith-ca/cytopathology/fs-emc-cytopath-feat.html "Cytopathologic Features of Epithelial-myoepithelial Carcinoma"]. http://www.pathologyimagesinc.com/sgt-cytopath/epith-myoepith-ca/cytopathology/fs-emc-cytopath-feat.html. Retrieved January 18, 2011.