Eosinophilic cholecystitis

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Eosinophilic cholecystitis is a rare type of cholecystitis.

Eosinophilic cholecystitis
Diagnosis in short

Eosinophilic cholecystitis. H&E stain. (WC)

LM gallbladder wall with inflammatory infiltrate that is >90% eosinophils
Subtypes (subtype of acute cholecystitis)
LM DDx acute cholecystitis with eosinophils
Site gallbladder

Associated Dx eosinophilic cholangitis, hypereosinophilic syndromes, parasitic infection
Signs see acute cholecystitis
Prevalence rare - case reports
Blood work +/-eosinophilia
Prognosis benign
Clin. DDx acute cholecystitis
Treatment cholecystectomy

General

Clinical associations:[1][3]

  • Eosinophilic cholangitis.
  • Hypereosinophilic syndromes (HES).
  • Parasitic infection.

Microscopic

Features:

  • Gallbladder wall with inflammatory infiltrate that is >90% eosinophils.[1][3]

DDx:

Images

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Gallbladder, Cholecystectomy:
- Eosinophilic cholecystitis and cholelithiasis, see comment.

Comment: 
Eosinophilic cholecystitis may be idiopathic or associated with other conditions characterized by eosinophilia, including but not limited to parasitic infections and hypereosinophilic syndromes. Clinical correlation is required.

Verbose

Gallbladder, Cholecystectomy:
     - Eosinophilic cholecystitis and cholelithiasis, see comment.

Comment:
The histopathologic diagnosis of eosinophilic cholecystitis is in keeping with the clinical impression of acute cholecystitis.

Eosinophilic cholecystitis may be idiopathic or associated with other conditions characterized by eosinophilia, including but not limited to parasitic infections and hypereosinophilic syndromes. Clinical correlation is required.

See also

References

  1. 1.0 1.1 1.2 Shakov, R.; Simoni, G.; Villacin, A.; Baddoura, W. (2007). "Eosinophilic cholecystitis, with a review of the literature.". Ann Clin Lab Sci 37 (2): 182-5. PMID 17522376.
  2. del-Moral-Martínez, M.; Barrientos-Delgado, A.; Crespo-Lora, V.; Cervilla-Sáez-de-Tejada, ME.; Salmerón-Escobar, J. (Jan 2015). "Eosinophilic cholecystitis: an infrequent cause of acute cholecystitis.". Rev Esp Enferm Dig 107 (1): 45-7. PMID 25603333.
  3. 3.0 3.1 Choudhury, M.; Pujani, M.; Katiyar, Y.; Jyotsna, PL.; Rautela, A. (2014). "Idiopathic eosinophilic cholecystitis with cholelithiasis: a report of two cases.". Turk Patoloji Derg 30 (2): 142-4. doi:10.5146/tjpath.2014.01235. PMID 24638193.