Difference between revisions of "Endometrial stromal sarcoma"

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{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Endometrial stromal sarcoma - low mag.jpg
| Width      =
| Caption    = Endometrial stromal sarcoma. [[H&E stain]].
| Micro      =
| Subtypes  =
| LMDDx      =
| Stains    =
| IHC        =
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Site      = [[uterus]] - see [[uterine tumours]]
| Assdx      =
| Syndromes  =
| Clinicalhx =
| Signs      =
| Symptoms  =
| Prevalence = rare
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  =
| Other      =
| ClinDDx    = other [[uterine tumours]]
}}
'''Endometrial stromal sarcoma''', abbreviated '''ESS''', is a rare malignant mesenchymal [[uterine tumours|tumour of the uterus]].
'''Endometrial stromal sarcoma''', abbreviated '''ESS''', is a rare malignant mesenchymal [[uterine tumours|tumour of the uterus]].


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===Images===
===Images===
*[http://commons.wikimedia.org/wiki/File:EndometrialStromalSarcoma.JPG ESS (WC)].
<gallery>
*[http://commons.wikimedia.org/wiki/File:EndometrialStromalSarcomaLowGrade.JPG Endometrial stromal sarcoma - low grade (WC)].
Image: Endometrial stromal sarcoma - low mag.jpg | ESS - low mag. (WC/Nephron)
Image: Endometrial stromal sarcoma - alt - low mag.jpg | ESS - low mag. (WC/Nephron)
Image: Endometrial stromal sarcoma - intermed mag.jpg | ESS - intermed. mag. (WC/Nephron)
Image: Endometrial stromal sarcoma - high mag.jpg | ESS - high mag. (WC/Nephron)
Image: Endometrial stromal sarcoma - very high mag.jpg | ESS - very high mag. (WC/Nephron)
</gallery>
<gallery>
Image:EndometrialStromalSarcoma.JPG | ESS. (WC)
Image:EndometrialStromalSarcomaLowGrade.JPG | Endometrial stromal sarcoma - low grade. (WC)
</gallery>
www:
*[http://jcp.bmj.com/content/60/3/235/F5.large.jpg ESS in an article with many crappy images].<ref name=pmid17347285>{{Cite journal  | last1 = Baker | first1 = P. | last2 = Oliva | first2 = E. | title = Endometrial stromal tumours of the uterus: a practical approach using conventional morphology and ancillary techniques. | journal = J Clin Pathol | volume = 60 | issue = 3 | pages = 235-43 | month = Mar | year = 2007 | doi = 10.1136/jcp.2005.031203 | PMID = 17347285 | url = http://jcp.bmj.com/content/60/3/235.full }}</ref>
*[http://jcp.bmj.com/content/60/3/235/F5.large.jpg ESS in an article with many crappy images].<ref name=pmid17347285>{{Cite journal  | last1 = Baker | first1 = P. | last2 = Oliva | first2 = E. | title = Endometrial stromal tumours of the uterus: a practical approach using conventional morphology and ancillary techniques. | journal = J Clin Pathol | volume = 60 | issue = 3 | pages = 235-43 | month = Mar | year = 2007 | doi = 10.1136/jcp.2005.031203 | PMID = 17347285 | url = http://jcp.bmj.com/content/60/3/235.full }}</ref>
*[http://radiographics.rsna.org/content/25/1/21/F42.expansion.html ESS (rsna.org)].
*[http://radiographics.rsna.org/content/25/1/21/F42.expansion.html ESS (rsna.org)].

Revision as of 03:29, 17 November 2013

Endometrial stromal sarcoma
Diagnosis in short

Endometrial stromal sarcoma. H&E stain.
Site uterus - see uterine tumours
Prevalence rare
Clin. DDx other uterine tumours

Endometrial stromal sarcoma, abbreviated ESS, is a rare malignant mesenchymal tumour of the uterus.

It is also known as low-grade endometrial stromal sarcoma

General

Microscopic

Features:

  • Highly cellular Islands with a wavy irregular border.
    • Border has finger-like projections/tongue-like projections.
    • Benign uterine smooth muscle between islands of tumour cells.
  • Epithelioid cells.
  • High NC ratio.
  • Thin blood vessels within islands of cells.
    • Tumour cells pallisade around the vessels.

Notes:

  • Vaguely resembles the stroma of proliferative endometrium.

DDx:

Images

  • ESS - low mag. (WC/Nephron)

  • ESS - low mag. (WC/Nephron)

  • ESS - intermed. mag. (WC/Nephron)

  • ESS - high mag. (WC/Nephron)

  • ESS - very high mag. (WC/Nephron)

  • ESS. (WC)

  • Endometrial stromal sarcoma - low grade. (WC)

www:

IHC

Features:[3]

  • CD10 +ve.
  • h-caldesmin -ve.
  • PR +/-ve.
  • ER +/-ve.

Molecular

May be associated a recurrent translocation:[4]

  • t(7;17)(p15;q21).
    • JAZF1 - chromosome 7.[5]
    • SUZ12 - chromosome 17.[6]

See also

References

  1. ↑ Chew, I.; Oliva, E. (Mar 2010). "Endometrial stromal sarcomas: a review of potential prognostic factors.". Adv Anat Pathol 17 (2): 113-21. doi:10.1097/PAP.0b013e3181cfb7c2. PMID 20179433.
  2. ↑ Baker, P.; Oliva, E. (Mar 2007). "Endometrial stromal tumours of the uterus: a practical approach using conventional morphology and ancillary techniques.". J Clin Pathol 60 (3): 235-43. doi:10.1136/jcp.2005.031203. PMID 17347285. http://jcp.bmj.com/content/60/3/235.full.
  3. ↑ Zhu, XQ.; Shi, YF.; Cheng, XD.; Zhao, CL.; Wu, YZ. (Jan 2004). "Immunohistochemical markers in differential diagnosis of endometrial stromal sarcoma and cellular leiomyoma.". Gynecol Oncol 92 (1): 71-9. PMID 14751141.
  4. ↑ Amant, F.; Moerman, P.; Cadron, I.; Hagemeijer, A.; Vergote, I.; Debiec-Rychter, M. (Mar 2003). "Endometrial stromal sarcoma with a sole t(X;17) chromosome change: report of a case and review of the literature.". Gynecol Oncol 88 (3): 459-62. PMID 12648605.
  5. ↑ Online 'Mendelian Inheritance in Man' (OMIM) 606246
  6. ↑ Online 'Mendelian Inheritance in Man' (OMIM) 606245
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