Diffuse lung diseases
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Diffuse lung diseases, abbreviated DLD, are a group of uncommon pathologies, also known as idiopathic interstitial pneumonias, abbreviated IIPs. They are a subgroup of the medical lung diseases.
An introduction to pulmonary pathology is found in the pulmonary pathology article.
- Often abbreviated IIP, is a term used for a type of diffuse lung disease.
- Diffuse lung disease is also known as interstitial lung disease.
- Diffuse lung disease is probably a better term... as some diseases lumped into this category have involvement of the alveoli, i.e. are not interstitial.
- Diffuse lung disease is also known as interstitial lung disease.
Overivew - histologic classification=
- Can be complex,[1] and the combined efforts of clinicians, radiologists, and pathologists can help in the generation of a more specific diagnosis.[2][3]
Idiopathic interstitial pneumonia can be subclassified based on histologic appearance into the following patterns:[4][5]
| Histology | Clinical Correlates | Associations |
|---|---|---|
| Desquamative interstitial pneumonia (DIP) | DIP | Smoking |
| Diffuse alveolar damage (DAD) | ARDS, AIP, TRALI | ARDS: trauma, infection; TRALI: blood transfusion; AIP: viral (???) |
| Nonspecific interstitial pneumonia (NSIP) | NSIP | ??? |
| Respiratory bronchiolitis | RB-ILD | Smoking |
| Usual interstitial pneumonia (UIP) | CVD, IPF, drug toxicity, pneumoconiosis | Allergen (hypersensitivity pneumonitis), idiopathic, autoimmune |
| Organizing pneumonia | Cryptogenic organizing pneumonia | autoimmune (???) |
| Lymphoid interstitial pneumonia (LIP) | LIP | Viral/autoimmune |
ARDS = adult respiratory distress syndrome, AIP = acute interstitial pneumonia, TRALI = transfusion related acute lung injury, CVD = collagen vascular disease, IPF = idiopathic pulmonary fibrosis.
Notes:
- Usual interstitial pneumonia is the most common type of ILD.[6]
See also
References
- ↑ Nicholson AG (November 2002). "Classification of idiopathic interstitial pneumonias: making sense of the alphabet soup". Histopathology 41 (5): 381-91. PMID 12405906. http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0309-0167&date=2002&volume=41&issue=5&spage=381.
- ↑ Flaherty KR, King TE, Raghu G, et al (October 2004). "Idiopathic interstitial pneumonia: what is the effect of a multidisciplinary approach to diagnosis?". Am. J. Respir. Crit. Care Med. 170 (8): 904-10. doi:10.1164/rccm.200402-147OC. PMID 15256390. http://ajrccm.atsjournals.org/cgi/pmidlookup?view=long&pmid=15256390.
- ↑ Kim DS, Collard HR, King TE (June 2006). "Classification and natural history of the idiopathic interstitial pneumonias". Proc Am Thorac Soc 3 (4): 285-92. doi:10.1513/pats.200601-005TK. PMID 16738191. http://pats.atsjournals.org/cgi/pmidlookup?view=long&pmid=16738191.
- ↑ Leslie KO, Wick MR. Practical Pulmonary Pathology: A Diagnostic Approach. Elsevier Inc. 2005. ISBN 978-0-443-06631-3.
- ↑ "American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias. This joint statement of the American Thoracic Society (ATS), and the European Respiratory Society (ERS) was adopted by the ATS board of directors, June 2001 and by the ERS Executive Committee, June 2001". Am. J. Respir. Crit. Care Med. 165 (2): 277-304. January 2002. PMID 11790668. http://ajrccm.atsjournals.org/cgi/pmidlookup?view=long&pmid=11790668.
- ↑ Visscher DW, Myers JL (June 2006). "Histologic spectrum of idiopathic interstitial pneumonias". Proc Am Thorac Soc 3 (4): 322-9. doi:10.1513/pats.200602-019TK. PMID 16738196. http://pats.atsjournals.org/cgi/pmidlookup?view=long&pmid=16738196.