Cutaneous calcinosis
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Cutaneous calcinosis | |
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Diagnosis in short | |
Cutaneous calcinosis. H&E stain. | |
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Synonyms | cutaneous calcification, calcinosis cutis |
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LM | dermal calcification - usu. well-circumscribed |
Gross | firm nodule |
Site | skin, scrotum |
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Clinical history | +/-trauma at the site |
Signs | firm nodule |
Prevalence | uncommon |
Prognosis | benign |
Treatment | excision |
Cutaneous calcinosis, also calcinosis cutis and cutaneous calcification, is calcification of the skin. It is benign in itself; however, the underlying cause may not be.
General
- Benign in itself; underlying cause may not be benign.
- May be a scrotal lesion - known as scrotal calcinosis.[1]
Subtypes:[2]
- Dystrophic - due to death of cells; may be related to a tumour.
- Metastatic - due to chronic renal failure; hyperkalemia; paraneoplastic phenomenon.
- Iatrogenic - post surgical.
- Idiopathic.
Gross
- Firm nodule.
Microscopic
Features:
- Dermal calcification:
- Acellular purple blobs on H&E.
- +/-Artefactual tearing of surrounding tissue due to processing (cutting).
- +/-Small artefactual lines ~1-2 micrometers due to processing (cutting).
- +/-Greyish rim of paucicellular material.
- Usu. well-circumscribed.
- May be surrounded by a palisading granuloma & giant cells.
- Acellular purple blobs on H&E.
Images
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SKIN AND SUBCUTANEOUS LESION, LEFT HIP, EXCISION: - SUBCUTANEOUS CALCIFICATION SURROUNDED BY BENIGN FIBROUS TISSUE. - DERMAL SCAR. - NEGATIVE FOR MALIGNANCY.
SUBCUTANEOUS MASS, OVER BURSA OF ELBOW, EXCISION: - CALCINOSIS CUTIS.
Micro
The sections show calcifications surrounded by macrophages and giant cells. No nuclear atypia is apparent. The overlying epidermis is unremarkable.
Without epidermis
The sections show dermal/subcutaneous calcifications surrounded by fibrosis, macrophages and giant cells. No nuclear atypia is apparent. Overlying epidermis is absent.
See also
References
- ↑ Dubey, S.; Sharma, R.; Maheshwari, V. (2010). "Scrotal calcinosis: idiopathic or dystrophic?". Dermatol Online J 16 (2): 5. PMID 20178701.
- ↑ URL: http://emedicine.medscape.com/article/1103137-overview. Accessed on: 21 September 2011.