Complex sclerosing lesion
Jump to navigation
Jump to search
The printable version is no longer supported and may have rendering errors. Please update your browser bookmarks and please use the default browser print function instead.
| Complex sclerosing lesion | |
|---|---|
| Diagnosis in short | |
 Complex sclerosing lesion of breast. H&E stain. (WC) | |
|
| |
| Synonyms | radial scar |
|
| |
| LM | stellate lesion (low magnification), center of lesion has fibroelastosis (stroma light pink on H&E), scar like stroma with entrapped normal breast ducts and lobules - glands appear to enlarge with distance from center of lesion |
| LM DDx | invasive ductal carcinoma |
| IHC | myoepithelial cells preset (p63 +ve, calponin +ve) |
| Gross | spiculated mass |
| Site | breast |
|
| |
| Prognosis | benign, increased risk of malignancy |
| Clin. DDx | breast cancer |
| Treatment | excision |
Complex sclerosing lesion (abbreviated CSL), also radial scar, is a benign lesion of the breast that is associated with an increased risk of subsequent breast cancer.
General
- The term radial scar is a misnomer. It isn't a scar. It isn't associated with prior trauma or surgery.[1]
- May appear malignant on imaging.[2]
- Associated with subsequent elevated risk of breast cancer.[4]
- Management - usually surgical excision.[5]
- Risk of malignancy on surgical excision for biopsy diagnosed CSLs very small ~1%.[6]
- Rare - less than 0.1% of core needle biopsies.[7]
Gross
- Spiculated mass.
- Usually small - 3-7 mm.
Image
Radial scar - gross. (WC)
Microscopic
- Stellate appearance (low magnification).
- Center of lesion has "fibroelastosis" - stroma light pink (on H&E) - key feature.
- Scar like stroma with entrapped normal breast ducts and lobules.
- Glands appear to enlarge with distance from center of lesion.
Notes:
- Histomorphologic appearance may mimic a desmoplastic reaction of the stroma - leading to a misdiagnosis of malignancy.
- "Hyaline - pink stuff on H&E - is the key."
DDx:
- Invasive ductal carcinoma - should be considered if the lesion is asymmetrical or glands are dilated centrally.
Images
RS - low mag. (WC)
RS - intermed. mag. (WC)
www
IHC
Features:
- p63 +ve.
- Calponin +ve.
Note:
- HMWK +ve/-ve. (???)
Sign out
Right Breast, Partial Mastectomy:
- Complex sclerosing lesion / radial scar.
- Background breast with proliferative fibrocystic changes and apocrine metaplasia.
- NEGATIVE for malignancy.
See also
References
- ↑ Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; Aster, Jon (2009). Robbins and Cotran pathologic basis of disease (8th ed.). Elsevier Saunders. pp. 1072. ISBN 978-1416031215.
- ↑ Ung OA, Lee WB, Greenberg ML, Bilous M (January 2001). "Complex sclerosing lesion: the lesion is complex, the management is straightforward". ANZ J Surg 71 (1): 35–40. PMID 11167596.
- ↑ Myong, JH.; Choi, BG.; Kim, SH.; Kang, BJ.; Lee, A.; Song, BJ. (Jan 2014). "Imaging features of complex sclerosing lesions of the breast.". Ultrasonography 33 (1): 58-64. doi:10.14366/usg.13015. PMID 24936496.
- ↑ URL: http://www.cancer.org/docroot/NWS/content/NWS_1_1x_Radial_Scars.asp. Accessed on: 4 May 2010.
- ↑ 5.0 5.1 Kennedy M, Masterson AV, Kerin M, Flanagan F (October 2003). "Pathology and clinical relevance of radial scars: a review". J. Clin. Pathol. 56 (10): 721–4. PMC 1770086. PMID 14514771. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1770086/.
- ↑ Li, Z.; Ranade, A.; Zhao, C. (Feb 2016). "Pathologic findings of follow-up surgical excision for radial scar on breast core needle biopsy.". Hum Pathol 48: 76-80. doi:10.1016/j.humpath.2015.06.028. PMID 26772402.
- ↑ Nassar, A.; Conners, AL.; Celik, B.; Jenkins, SM.; Smith, CY.; Hieken, TJ. (Feb 2015). "Radial scar/complex sclerosing lesions: a clinicopathologic correlation study from a single institution.". Ann Diagn Pathol 19 (1): 24-8. doi:10.1016/j.anndiagpath.2014.12.003. PMID 25578683.
- ↑ O'Malley, Frances P.; Pinder, Sarah E. (2006). Breast Pathology: A Volume in Foundations in Diagnostic Pathology series (1st ed.). Churchill Livingstone. pp. 91. ISBN 978-0443066801.