Difference between revisions of "Collagenous sprue"

From Libre Pathology
Jump to navigation Jump to search
Line 1: Line 1:
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      =
| Width      =
| Caption    =
| Synonyms  =
| Micro      = subepithelial collagen layer > 12 micrometres, villous atrophy, crypt atrophy.
| Subtypes  =
| LMDDx      = [[celiac disease]]
| Stains    = demonstrate collagen - [[Masson trichrome]], [[Mallory trichrome]]
| IHC        =
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Site      = [[small bowel]]
| Assdx      = possibly [[celiac disease]]
| Syndromes  =
| Clinicalhx = unresponsive to gluten free diet
| Signs      =
| Symptoms  =
| Prevalence = very rare
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  =
| Other      =
| ClinDDx    =
| Tx        =
}}
'''Collagenous sprue''' is a very rare disorder of the [[small bowel]]. There are approximately 60 reported cases in the world literature.<ref name=pmid21631278 >{{Cite journal  | last1 = Zhao | first1 = X. | last2 = Johnson | first2 = RL. | title = Collagenous sprue: a rare, severe small-bowel malabsorptive disorder. | journal = Arch Pathol Lab Med | volume = 135 | issue = 6 | pages = 803-9 | month = Jun | year = 2011 | doi = 10.1043/2010-0028-RS.1 | PMID = 21631278 }}</ref>  
'''Collagenous sprue''' is a very rare disorder of the [[small bowel]]. There are approximately 60 reported cases in the world literature.<ref name=pmid21631278 >{{Cite journal  | last1 = Zhao | first1 = X. | last2 = Johnson | first2 = RL. | title = Collagenous sprue: a rare, severe small-bowel malabsorptive disorder. | journal = Arch Pathol Lab Med | volume = 135 | issue = 6 | pages = 803-9 | month = Jun | year = 2011 | doi = 10.1043/2010-0028-RS.1 | PMID = 21631278 }}</ref>  



Revision as of 13:41, 26 December 2013

Collagenous sprue
Diagnosis in short

LM subepithelial collagen layer > 12 micrometres, villous atrophy, crypt atrophy.
LM DDx celiac disease
Stains demonstrate collagen - Masson trichrome, Mallory trichrome
Site small bowel

Associated Dx possibly celiac disease
Clinical history unresponsive to gluten free diet
Prevalence very rare

Collagenous sprue is a very rare disorder of the small bowel. There are approximately 60 reported cases in the world literature.[1]

General

Clinical:

  • Diarrhea.
    • Not responsive to Gluten-free diet.

Microscopic

Features:[1]

  • Subepithelial collagen layer > 12 micrometres - key feature.
  • Villous atrophy.
  • Crypt atrophy.

DDx:

Images

See also

References

  1. 1.0 1.1 1.2 Zhao, X.; Johnson, RL. (Jun 2011). "Collagenous sprue: a rare, severe small-bowel malabsorptive disorder.". Arch Pathol Lab Med 135 (6): 803-9. doi:10.1043/2010-0028-RS.1. PMID 21631278.
  2. Busto-Bea, V.; Crespo-Pérez, L.; García-Miralles, N.; Ruiz-Del-Árbol-Olmos, L.; Cano-Ruiz, A. (May 2013). "Collagenous sprue: Don´t forget connective tissue in chronic diarrhea evaluation.". Rev Esp Enferm Dig 105 (3): 171-174. PMID 23735026.
  3. Vakiani, E.; Arguelles-Grande, C.; Mansukhani, MM.; Lewis, SK.; Rotterdam, H.; Green, PH.; Bhagat, G. (Jan 2010). "Collagenous sprue is not always associated with dismal outcomes: a clinicopathological study of 19 patients.". Mod Pathol 23 (1): 12-26. doi:10.1038/modpathol.2009.151. PMID 19855376.
  4. Xiao, Z.; Dasari, VM.; Kirby, DF.; Bronner, M.; Plesec, TP.; Lashner, BA. (Jun 2009). "Collagenous sprue: a case report and literature review.". Gastroenterol Hepatol (N Y) 5 (6): 418-24. PMID 20574500.