Difference between revisions of "Collagenous sprue"
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'''Collagenous sprue''' is a very rare disorder of the [[small bowel]] | '''Collagenous sprue''' is a very rare disorder of the [[small bowel]]. There are approximately 60 reported cases in the world literature.<ref name=pmid21631278 >{{Cite journal | last1 = Zhao | first1 = X. | last2 = Johnson | first2 = RL. | title = Collagenous sprue: a rare, severe small-bowel malabsorptive disorder. | journal = Arch Pathol Lab Med | volume = 135 | issue = 6 | pages = 803-9 | month = Jun | year = 2011 | doi = 10.1043/2010-0028-RS.1 | PMID = 21631278 }}</ref> | ||
==General== | ==General== | ||
Revision as of 03:32, 9 June 2013
Collagenous sprue is a very rare disorder of the small bowel. There are approximately 60 reported cases in the world literature.[1]
General
- Thought to be related to celiac sprue - though somewhat controversial.[1][2]
Clinical:
- Diarrhea.
- Not responsive to Gluten-free diet.
Microscopic
Features:[1]
- Subepithelial collagen layer > 12 micrometres - key feature.
- Villous atrophy.
- Crypt atrophy.
DDx:
See also
References
- ↑ 1.0 1.1 1.2 Zhao, X.; Johnson, RL. (Jun 2011). "Collagenous sprue: a rare, severe small-bowel malabsorptive disorder.". Arch Pathol Lab Med 135 (6): 803-9. doi:10.1043/2010-0028-RS.1. PMID 21631278.
- ↑ Busto-Bea, V.; Crespo-Pérez, L.; García-Miralles, N.; Ruiz-Del-Árbol-Olmos, L.; Cano-Ruiz, A. (May 2013). "Collagenous sprue: Don´t forget connective tissue in chronic diarrhea evaluation.". Rev Esp Enferm Dig 105 (3): 171-174. PMID 23735026.