Chondroma
Jump to navigation
Jump to search
The printable version is no longer supported and may have rendering errors. Please update your browser bookmarks and please use the default browser print function instead.
| Chondroma | |
|---|---|
| Diagnosis in short | |
 Enchondroma. H&E stain. | |
|
| |
| LM | cytologically benign cells is spaced nests, should not extend into surrounding soft tissue |
| LM DDx | low-grade chondrosarcoma |
| Site | cartilage - see chondro-osseous tumours |
|
| |
| Syndromes | Ollier disease, Maffucci syndrome, metachondromatosis |
|
| |
| Prognosis | benign |
Chondroma is a benign tumour of cartilage. It is in the chondro-osseous tumours group of soft tissue tumours.
General
- Benign thingy.
- Usual legs and feet.
- May be difficult to separate from chondrosarcoma.
- Multiple chondromas = enchondromatosis; three distinct syndromes:[1]
- Ollier disease.
- Maffucci syndrome - with hemangiomas, increased risk of chondrosarcoma.[2]
- Metachondromatosis - autosomal dominant.
- Enchondroma = chondroma in the marrow space.
Clinical:[1]
- Pain.
Radiology
Features:[1]
- Lytic lesion.
- Usual close to a growth plate.
Important suspicious findings that favour malignant:[3]
- Cortical destruction.
- Soft tissue component.
Note:
- High-grade chondroid lesions (high-grade chondrosarcoma) can usually be separated radiologically from low-grade ones.[4]
Microscopic
Features:
- Cytologically benign cells is spaced nests.
- Should not extending into surrounding soft tissue.
DDx:
- Low-grade chondrosarcoma - should be considered, correlation with radiology essential.
Images
Enchondroma - intermed mag. (WC)
Enchondroma - very high mag. (WC)
Sign out
TISSUE ("CHONDROMA"), LEFT COSTAL MARGIN, EXCISION:
- CHONDROMA.
Micro
The sections show spaced small cells in a pale matrix with a light-blue tinge. No nuclear atypia is appreciated. No mitotic activity is apparent. Degenerative changes are seen focally.
A small focus of cholesterol clefts with giant cells is present. Benign bone, bone marrow and skeletal muscle are present.
See also
References
- ↑ 1.0 1.1 1.2 URL: http://emedicine.medscape.com/article/389224-overview. Accessed on: 25 December 2010.
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 166000
- ↑ Choi, BB.; Jee, WH.; Sunwoo, HJ.; Cho, JH.; Kim, JY.; Chun, KA.; Hong, SJ.; Chung, HW. et al. "MR differentiation of low-grade chondrosarcoma from enchondroma.". Clin Imaging 37 (3): 542-7. doi:10.1016/j.clinimag.2012.08.006. PMID 23041161.
- ↑ Berber, O.; Datta, G.; Sabharwal, S.; Aston, W.; Saifuddin, A.; Briggs, T. (Apr 2012). "The safety of direct primary excision of low-grade chondral lesions based on radiological diagnosis alone.". Acta Orthop Belg 78 (2): 254-62. PMID 22696998.