Difference between revisions of "Chondroblastoma"

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*Growth plate lesion.
*Growth plate lesion.
*Sclerotic margin.
*Sclerotic margin.
*"Young" = growth plates open.  Children, young adults.
*"Young" = growth plates open.   
*Most common in teens.
*Typically painful.<ref name=Ref_PCPBoD8_625>{{Ref PCPBoD8|625}}</ref>
*Typically painful.<ref name=Ref_PCPBoD8_625>{{Ref PCPBoD8|625}}</ref>
*Radiographic osteolytic lesion of the epiphysis [http://radiopaedia.org/articles/lytic-bone-lesion-mnemonic]
*Rare, 1 % of all bone tumors
*Rare, 1 % of all bone tumors
*Benign
*Benign
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Image:Bone Chondroblastoma Medium Power.jpg|Chicken wire calcification. (SKB)
Image:Bone Chondroblastoma Medium Power.jpg|Chicken wire calcification. (SKB)
Image:Bone Chondroblastoma High Power.jpg|Chicken wire calcification. (SKB)
Image:Bone Chondroblastoma High Power.jpg|Chicken wire calcification. (SKB)
Image:Bone Chondroblastoma and Aneurysmal Bone Cyst Low Power.jpg|Immature cartilage surrounded by aneurysmal bone cyst with giant cells. (SKB)
Image:Bone Chondroblastoma With Aneurysmal Bone Cyst - Medium Power.jpg|Immature cartilage (left) abutting aneurysmal bone cyst (right) with giant cells. (SKB)
Image:Bone Chondroblastoma With Aneurysmal Bone Cyst - Medium Power.jpg|Immature cartilage (left) abutting aneurysmal bone cyst (right) with giant cells. (SKB)
Image:Bone Chondroblastoma - Medium Power.jpg|thumb|Immature cartilage]]
Image:Bone Chondroblastoma - Medium Power.jpg|Immature cartilage. (SKB)
Image:Bone Chondroblastoma and Aneurysmal Bone Cyst Low Power.jpg|Immature cartilage surrounded by aneurysmal bone cyst with giant cells. (SKB)
Image:Bone Chondroblastoma and Aneurysmal Bone Cyst Low Power.jpg|Immature cartilage surrounded by aneurysmal bone cyst with giant cells. (SKB)
</gallery>
</gallery>
www:
www:
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*[http://img.medscape.com/pi/emed/ckb/orthopedic_surgery/1230552-1254949-997.jpg Chondroblastoma with "chickenwire" appearance (medscape.com)].<ref name=emed_chondroblastoma>URL: [http://emedicine.medscape.com/article/1254949-diagnosis http://emedicine.medscape.com/article/1254949-diagnosis]. Accessed on: 31 December 2010.</ref>
*[http://img.medscape.com/pi/emed/ckb/orthopedic_surgery/1230552-1254949-997.jpg Chondroblastoma with "chickenwire" appearance (medscape.com)].<ref name=emed_chondroblastoma>URL: [http://emedicine.medscape.com/article/1254949-diagnosis http://emedicine.medscape.com/article/1254949-diagnosis]. Accessed on: 31 December 2010.</ref>
*[http://path.upmc.edu/cases/case494/images/fig2a.jpg Chondroblastoma (upmc.edu)].<ref>URL: [http://path.upmc.edu/cases/case494.html http://path.upmc.edu/cases/case494.html]. Accessed on: 24 January 2012.</ref>
*[http://path.upmc.edu/cases/case494/images/fig2a.jpg Chondroblastoma (upmc.edu)].<ref>URL: [http://path.upmc.edu/cases/case494.html http://path.upmc.edu/cases/case494.html]. Accessed on: 24 January 2012.</ref>
*Tumor Library - case with giant cells[http://www.tumorlibrary.com/case/image.jsp?title=Chondroblastoma+-+Distal+femur+-+Photomicrograph&uri=/case/images/3571.jpg]


==IHC==
==IHC==
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==See also==
==See also==
*[[Chondro-osseous tumours]].
*[[Chondro-osseous tumours]].
*Tumor Library[http://www.tumorlibrary.com/case/list.jsp?order=diagnosis+ASC&diagnosis=Chondroblastoma]


==References==
==References==

Latest revision as of 05:24, 21 October 2014

Chondroblastoma
Diagnosis in short

Chondroblastoma. H&E stain.

LM abundant (chondroid) extracellular material, chondroblasts (variable nuclear morphology (ovoid, folded or grooved), moderate-abundant eosinophilic cytoplasm), +/-calcifications surrounding the cell nests ("chickenwire" appearance) - classic feature, +/-giant cells
LM DDx giant cell tumour of bone, chondroma, well-differentiated chondrosarcoma
Site growth plate - see chondro-osseous tumours

Clinical history "young" - growth plates open
Symptoms painful
Prognosis benign

Chondroblastoma is a benign chondro-osseous tumour that afflicts the young (growth plates open).

General

  • Growth plate lesion.
  • Sclerotic margin.
  • "Young" = growth plates open.
  • Most common in teens.
  • Typically painful.[1]
  • Radiographic osteolytic lesion of the epiphysis [1]
  • Rare, 1 % of all bone tumors
  • Benign
  • Humerus, tibia, femur

Gross

  • Well-defined lesion.

Image

Microscopic

Features:[2]

  • Abundant extracellular material - pink on H&E stain - looks vaguely like cartilage.
  • Sometimes described as 'immature cartilage' (very narrow DDX for this type of cartilage)
  • Chondroblasts:
    • Nuclear morphology variable: ovoid, folded or grooved.
    • Moderate-abundant eosinophilic cytoplasm.
  • +/-Calcification surrounds the cell nests ("chickenwire" appearance) - classic feature.
    • Cell nests have a thin pale blue rimming.
  • +/-Giant cells.

DDx:

Images

www:

IHC

Features:[2]

  • S100 +ve.
  • Vimentin +ve.[4]

See also

References

  1. Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 625. ISBN 978-1416054542.
  2. 2.0 2.1 Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 642. ISBN 978-0781765275.
  3. Sepah, YJ.; Umer, M.; Minhas, K.; Hafeez, K. (2007). "Chondroblastoma of the cuboid with an associated aneurysmal bone cyst: a case report.". J Med Case Rep 1: 135. doi:10.1186/1752-1947-1-135. PMID 17999776.
  4. 4.0 4.1 4.2 URL: http://emedicine.medscape.com/article/1254949-diagnosis. Accessed on: 31 December 2010.
  5. URL: http://path.upmc.edu/cases/case494.html. Accessed on: 24 January 2012.