Difference between revisions of "Carcinoma ex pleomorphic adenoma"
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==Microscopic== | ==Microscopic== | ||
Features: | Features: | ||
*Cells with cytologic features of malignancy. | *Cells with cytologic features of malignancy - '''key feature'''. | ||
*Architecture (any of the following): | *Architecture (any of the following): | ||
**Glands. | **Glands. | ||
| Line 21: | Line 21: | ||
Architectural patterns: | Architectural patterns: | ||
*Ductal carcinoma NOS (arising from ductal cells) - most common pattern for Ca ex PA. | *[[Ductal carcinoma]] NOS (arising from ductal cells) - most common pattern for Ca ex PA. | ||
*Myoepithelial | *Myoepithelial carcinoma NOS (arising from myoepithelial cells). | ||
*"Named carcinoma": | *"Named carcinoma": | ||
**Salivary duct carcinoma - second most common pattern for Ca ex PA. | **[[Salivary duct carcinoma]] - second most common pattern for Ca ex PA. | ||
**Mucoepidermoid carcinoma. | **[[Mucoepidermoid carcinoma]]. | ||
**Adenoid cystic carcinoma. | **[[Adenoid cystic carcinoma]]. | ||
Note: | Note: | ||
*Often adenocarcinoma-like. | *Often adenocarcinoma-like. | ||
*Myoepithelial cells may be clear cells. | *Myoepithelial cells may be clear cells. | ||
DDx: | |||
*[[Salivary ducat carcinoma]]. | |||
*[[Mucoepidermoid carcinoma]]. | |||
*[[Adenoid cystic carcinoma]]. | |||
*[[Pleomorphic adenoma]]. | |||
===Subclassification=== | ===Subclassification=== | ||
Revision as of 17:11, 23 November 2013
Carcinoma ex pleomorphic adenoma, abbreviated ca ex PA, is a rare malignant salivary gland tumour that arise from a pleomorphic adenoma.
General
Definition:
- Malignant transformation of a pleomorphic adenoma.
Diagnosis (either 1 or 2):
- History of a pleomorphic adenoma at the same site.
- Features of a pleomorphic adenoma and a carcinoma.
Epidemiology:
- Rare.
Microscopic
Features:
- Cells with cytologic features of malignancy - key feature.
- Architecture (any of the following):
- Glands.
- Nests.
- Single cells (may be subtle).
Architectural patterns:
- Ductal carcinoma NOS (arising from ductal cells) - most common pattern for Ca ex PA.
- Myoepithelial carcinoma NOS (arising from myoepithelial cells).
- "Named carcinoma":
- Salivary duct carcinoma - second most common pattern for Ca ex PA.
- Mucoepidermoid carcinoma.
- Adenoid cystic carcinoma.
Note:
- Often adenocarcinoma-like.
- Myoepithelial cells may be clear cells.
DDx:
Subclassification
Extent of invasion:[1]
- Non-invasive AKA intracapsular AKA in situ.
- Minimally invasive <=1.5 mm beyond the capsule.
- Widely invasive >1.5 mm beyond the capsule.
See also
References
- ↑ URL: http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2011/MajorSalGlands_11protocol.pdf. Accessed on: 2 April 2012.