Carbonic anhydrase 9
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Carbonic anhydrase 9, abbreviated CA9 and CAIX, is a common immunostain used in genitourinary pathology.
General
- Several clones available - clone M75 most common.[1]
Staining
Positive
- Clear cell renal cell carcinoma.[2]
- 95% +ve with clone NB100-417 and clone M75.[1]
- Epithelioid mesothelioma.[3]
- Benign mesothelium.[4]
Negative
- Xp11.2 translocation carcinoma.[2]
- Breast carcinoma.[5] ‡
- Seminoma.[5]
Note:
- ‡ A paper by Furjelová et al. found different results.[6]
Images
CA9 - intermed. mag. (WC)
CA9 - high mag. (WC)
CA9 - very high mag. (WC)
See also
References
- ↑ 1.0 1.1 Al-Ahmadie, HA.; Alden, D.; Qin, LX.; Olgac, S.; Fine, SW.; Gopalan, A.; Russo, P.; Motzer, RJ. et al. (Mar 2008). "Carbonic anhydrase IX expression in clear cell renal cell carcinoma: an immunohistochemical study comparing 2 antibodies.". Am J Surg Pathol 32 (3): 377-82. doi:10.1097/PAS.0b013e3181570343. PMID 18300814.
- ↑ 2.0 2.1 Genega, EM.; Ghebremichael, M.; Najarian, R.; Fu, Y.; Wang, Y.; Argani, P.; Grisanzio, C.; Signoretti, S. (Dec 2010). "Carbonic anhydrase IX expression in renal neoplasms: correlation with tumor type and grade.". Am J Clin Pathol 134 (6): 873-9. doi:10.1309/AJCPPPR57HNJMSLZ. PMID 21088149.
- ↑ Ordóñez, NG. (Aug 2013). "Value of PAX8, PAX2, napsin A, carbonic anhydrase IX, and claudin-4 immunostaining in distinguishing pleural epithelioid mesothelioma from metastatic renal cell carcinoma.". Mod Pathol 26 (8): 1132-43. doi:10.1038/modpathol.2013.34. PMID 23503645.
- ↑ Ananthanarayanan, V.; Tretiakova, M.; Husain, AN.; Krausz, T.; Antic, T. (Jul 2014). "Carbonic anhydrase IX (CAIX) does not differentiate between benign and malignant mesothelium.". Am J Clin Pathol 142 (1): 82-7. doi:10.1309/AJCP8BJ8CJXUEHZD. PMID 24926090.
- ↑ 5.0 5.1 Luong-Player, A.; Liu, H.; Wang, HL.; Lin, F. (Feb 2014). "Immunohistochemical reevaluation of carbonic anhydrase IX (CA IX) expression in tumors and normal tissues.". Am J Clin Pathol 141 (2): 219-25. doi:10.1309/AJCPVJDS28KNYZLD. PMID 24436269.
- ↑ Furjelová, M.; Kovalská, M.; Jurková, K.; Horáček, J.; Carbolová, T.; Adamkov, M. (Jan 2014). "Carbonic anhydrase IX: a promising diagnostic and prognostic biomarker in breast carcinoma.". Acta Histochem 116 (1): 89-93. doi:10.1016/j.acthis.2013.05.009. PMID 23816158.