Branchial cleft cyst
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Branchial cleft cyst, also branchial cleft remnant, is a benign congenital lesion of the head and neck.
General
- Benign congenital thingy in the lateral neck.[1]
- Most common cystic neck lesion in young adults.[2]
- Treatment: excision.
Gross
- Lateral neck mass.
Image - clinical:
Microscopic
Features:
- Cystic space lined by squamous epithelium - usually.
- +/-Inflammation.
- Connective tissue:
- +/-Adipose tissue.
- +/-Cartilage.
- +/-Bone.
- +/-Muscle.
DDx:
- Cystic squamous cell carcinoma - may be deceptively benign appearing.[2]
- Papillary thyroid carcinoma (PTC) arising in a brachial cleft cyst[3] - uncommon, looks like PTC in the thyroid.
- Epidermal inclusion cyst.
Images
IHC
- p16 -ve.
- May be done to exclude a HPV-associated head and neck squamous cell carcinoma.
- Ki-67 low.
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Right Neck Mass, Fine Needle Aspiration (FNA): - Benign squamous cells and debris admixed in a background of inflammatory cells. - Moderately cellular specimen. Comment: The differential diagnosis includes branchial cleft cyst and epidermal inclusion cyst. Clinical correlation is required.
See also
References
- ↑ URL: http://www.childrenshospital.org/az/Site663/mainpageS663P0.html. Accessed on: 15 March 2011.
- ↑ 2.0 2.1 Pietarinen-Runtti, P.; Apajalahti, S.; Robinson, S.; Passador-Santos, F.; Leivo, I.; Mäkitie, AA. (Feb 2010). "Cystic neck lesions: clinical, radiological and differential diagnostic considerations.". Acta Otolaryngol 130 (2): 300-4. doi:10.3109/00016480903127450. PMID 19593684.
- ↑ Park, J.; Kwon, SY.; Kim, NH.; Baik, SH.; Choi, DS. (Mar 2010). "Papillary thyroid carcinoma arising in a branchial cleft cyst.". Thyroid 20 (3): 347-9. doi:10.1089/thy.2009.0124. PMID 20187788.