Ber-EP4
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Ber-EP4 is a commonly available immunostain. It is directed against EpCam.[1]
Positive
- Basal cell carcinoma.
- Lung adenocarcinoma (55 positive of 59 cases[2]).
Negative
- Squamous cell carcinoma of the skin.[3]
- Malignant mesothelioma (18 positive of 70 cases[2]).
- Microcystic adnexal carcinoma.[4]
See also
References
- ↑ Dasgeb, B.; Mohammadi, TM.; Mehregan, DR. (2013). "Use of Ber-EP4 and Epithelial Specific Antigen to Differentiate Clinical Simulators of Basal Cell Carcinoma.". Biomark Cancer 5: 7-11. doi:10.4137/BIC.S11856. PMID 24179394.
- ↑ 2.0 2.1 Ordóñez, NG. (Jan 1998). "Value of the Ber-EP4 antibody in differentiating epithelial pleural mesothelioma from adenocarcinoma. The M.D. Anderson experience and a critical review of the literature.". Am J Clin Pathol 109 (1): 85-9. PMID 9426522.
- ↑ Yu, L.; Galan, A.; McNiff, JM. (Oct 2009). "Caveats in BerEP4 staining to differentiate basal and squamous cell carcinoma.". J Cutan Pathol 36 (10): 1074-176. doi:10.1111/j.1600-0560.2008.01223.x. PMID 19187107.
- ↑ Sellheyer, K.; Nelson, P.; Kutzner, H.; Patel, RM. (Apr 2013). "The immunohistochemical differential diagnosis of microcystic adnexal carcinoma, desmoplastic trichoepithelioma and morpheaform basal cell carcinoma using BerEP4 and stem cell markers.". J Cutan Pathol 40 (4): 363-70. doi:10.1111/cup.12085. PMID 23398472.