Basal cell adenocarcinoma

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Basal cell adenocarcinoma, abbreviated BCAC, is an uncommon malignant salivary gland tumour.

Basal cell adenocarcinoma
Diagnosis in short

Basal cell adenocarcinoma. H&E stain.

LM unencapsulated lesion with basal-like cells, tubular component - within basal component, dense hyaline stroma around tumour cells
LM DDx adenoid cystic carcinoma, basal cell adenoma - cannot be differentiated on cytology
Site salivary gland - usu. parotid gland

Signs salivary gland mass
Prevalence very rare
Prognosis good

It should not be confused with basal cell carcinoma, a very common tumour of the skin.

General

Gross

  • Usually in the parotid gland ~90% of cases.[1]

Microscopic

Features:

  1. Lesion is not encapsulated - key feature.
  2. Basal-like cells:
    • Basophilic cells - key feature.
    • Usually in nests.
    • Large basophilic nucleus.
    • Minimal-to-moderate eosinophilic cytoplasm.
  3. Stromal cells.
    • Plump spindle cells without significant nuclear atypia.
      • Stromal cell nuclei width ~= diameter RBC.
    • Dense hyaline stroma.
  4. Tubular component.
    • Within basal component, may be minimal.

DDx:

Images

www:

IHC

Features:[2]

  • CK7 +ve (strong).
  • S100 +ve/-ve.

See also

References

  1. 1.0 1.1 Muller, S.; Barnes, L. (Dec 1996). "Basal cell adenocarcinoma of the salivary glands. Report of seven cases and review of the literature.". Cancer 78 (12): 2471-7. PMID 8952553.
  2. Farrell, T.; Chang, YL. (Oct 2007). "Basal cell adenocarcinoma of minor salivary glands.". Arch Pathol Lab Med 131 (10): 1602-4. doi:10.1043/1543-2165(2007)131[1602:BCAOMS]2.0.CO;2. PMID 17922602.