Atypical spindle cell lesions of the skin

Atypical spindle cell lesions of the skin are seen with some frequency.

Classic

The differential diagnosis of atypical skin spindle cell lesions is SLAM:

• Spindle cell squamous cell carcinoma.
• Leiomyosarcoma.
• Atypical fibroxanthoma.
• Malignant melanoma.

Extended

A longer differential diagnosis that includes lesions with less atypia is SLAM DUNK:

• Spindle cell squamous cell carcinoma.
• Leiomyosarcoma.
• Angiosarcoma.
• Malignant melanoma.
• Dermatofibrosarcoma protuberans (DFSP).
• Undifferentiated pleomorphic sarcoma (AFX).
• Nodular fasciitis.
• Kaposi sarcoma.

See also

• Dermatopathology.
• Spindle cell lesions.