Difference between revisions of "Arias-Stella reaction"

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*[[Choriocarcinoma]].
*[[Choriocarcinoma]].
*[[Herpes simplex virus|Herpetic]] [[endometritis]].
*[[Herpes simplex virus|Herpetic]] [[endometritis]].
*[[Endometrial clear cell carcinoma]].
*[[Clear cell endometrial carcinoma]].
*[[Serous endometrial carcinoma]].<ref name=pmid20173505>{{Cite journal  | last1 = Félix | first1 = A. | last2 = Nogales | first2 = FF. | last3 = Arias-Stella | first3 = J. | title = Polypoid endometriosis of the uterine cervix with Arias-Stella reaction in a patient taking phytoestrogens. | journal = Int J Gynecol Pathol | volume = 29 | issue = 2 | pages = 185-8 | month = Mar | year = 2010 | doi = 10.1097/PGP.0b013e3181b7015e | PMID = 20173505 }}</ref>


Images:
Images:

Revision as of 04:27, 26 June 2012

The Arias-Stella reaction is a benign change.

General

Note:

  • To the novice... the nuclei look really scary, i.e. they look like cancer.

Microscopic

Features:[1]

  • Epithelial component of endometrium with large nuclei - key feature.
  • NC ratio is preserved.[2]
  • Usually a focal change.
  • +/-Mitoses - uncommon.

Notes:

  • No decidual reaction in the stroma.

DDx:

Images:

Subtypes

There are five subtypes:[1]

  1. Minimal atypia.
    • Usually early gestation.
  2. Early secretory pattern.
    • Mimics secretory endometrium: cytoplasmic vacuoles, central nucleus, palisading architecture.
  3. Secretory or hypersecretory pattern.
  4. Regenerative, proliferative or nonsecretory pattern.
  5. Monstrous cell pattern.

See also

References

  1. 1.0 1.1 1.2 Arias-Stella, J. (Jan 2002). "The Arias-Stella reaction: facts and fancies four decades after.". Adv Anat Pathol 9 (1): 12-23. PMID 11756756.
  2. 2.0 2.1 Tadrous, Paul.J. Diagnostic Criteria Handbook in Histopathology: A Surgical Pathology Vade Mecum (1st ed.). Wiley. pp. 236-7. ISBN 978-0470519035. . Cite error: Invalid <ref> tag; name "Ref_DCHH236-7" defined multiple times with different content
  3. Félix, A.; Nogales, FF.; Arias-Stella, J. (Mar 2010). "Polypoid endometriosis of the uterine cervix with Arias-Stella reaction in a patient taking phytoestrogens.". Int J Gynecol Pathol 29 (2): 185-8. doi:10.1097/PGP.0b013e3181b7015e. PMID 20173505.