From Libre Pathology
Jump to navigation Jump to search

Angiomyofibroblastoma, abbreviated AMF,[1] is rare uncommon soft tissue lesion of the vulva.

Diagnosis in short

Angiomyofibroblastoma. H&E stain.

LM hypercellular zones and hypocellular edematous zones, small blood vessels (~20 micrometers) - no large blood vessels, myxoid stroma, small stellate cell/spindle cells without significant nuclear atypia
LM DDx aggressive angiomyxoma
Gross well-circumscribed
Site female pelvis (vulva), case reports of similar lesion in males

Clinical history slow growing, usu. not painful
Prevalence very rare
Clin. DDx Bartholin cyst, aggressive angiomyxoma


  • Uncommon.
  • Similar lesions reported in males.[2][3]


  • Slow growing.
  • Uncommonly recur.
  • Usually painless.

Clinical DDx:




  • Hypercellular zones and hypocellular edematous zones.
  • Small blood vessels (~20 micrometers) - no large blood vessels - key feature.
  • Myxoid stroma - key feature.
  • Small stellate cell/spindle cells without significant nuclear atypia.





  • Desmin +ve.[4]
  • Vimentin +ve.[4]
  • SMA +ve.
  • S-100 -ve.
  • Actin -ve.
  • CD34 -ve.

See also


  1. Cao D, Srodon M, Montgomery EA, Kurman RJ (April 2005). "Lipomatous variant of angiomyofibroblastoma: report of two cases and review of the literature". Int. J. Gynecol. Pathol. 24 (2): 196–200. PMID 15782077.
  2. 2.0 2.1 Ding, G.; Yu, Y.; Jin, M.; Xu, J.; Zhang, Z. (Feb 2014). "Angiomyofibroblastoma-like tumor of the scrotum: A case report and literature review.". Oncol Lett 7 (2): 435-438. doi:10.3892/ol.2013.1741. PMID 24396463.
  3. Butt, Z.; Slatnik, J.; Estey, EP. (Dec 2013). "Robotic assisted laparoscopic excision of a pelvic angiomyofibroblastoma-like tumor.". Can J Urol 20 (6): 7067-9. PMID 24331351.
  4. 4.0 4.1 4.2 4.3 Seo, JW.; Lee, KA.; Yoon, NR.; Lee, JW.; Kim, BG.; Bae, DS. (Sep 2013). "Angiomyofibroblastoma of the vulva.". Obstet Gynecol Sci 56 (5): 349-51. doi:10.5468/ogs.2013.56.5.349. PMID 24328028.
  5. Fletcher, CD.; Tsang, WY.; Fisher, C.; Lee, KC.; Chan, JK. (Apr 1992). "Angiomyofibroblastoma of the vulva. A benign neoplasm distinct from aggressive angiomyxoma.". Am J Surg Pathol 16 (4): 373-82. PMID 1314521.