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Angioinvasion, also vascular invasion, is spread of tumour into a blood vessel.[1]

Angioinvasion is typically lumped with lymphatic invasion and referred to as lymphovascular invasion. This article only deals with angioinvasion.


  • The distinction between lymphatic invasion and lymphovascular invasion is usually not important. One important exception is the thyroid gland.[2]

Vascular invasion is occasionally seen in the benign tumours:



  • Tumour within a vascular space.
    • Vascular space: endothelial cells, red blood cells.


  • One strict definitions requires thrombus adherent to tumour.[2]


See also


  1. URL: Accessed on: 24 November 2016.
  2. 2.0 2.1 Mete, O.; Asa, SL. (Dec 2011). "Pathological definition and clinical significance of vascular invasion in thyroid carcinomas of follicular epithelial derivation.". Mod Pathol 24 (12): 1545-52. doi:10.1038/modpathol.2011.119. PMID 21804527.
  3. Wobker, SE.; Przybycin, CG.; Sircar, K.; Epstein, JI. (Dec 2016). "Renal oncocytoma with vascular invasion: a series of 22 cases.". Hum Pathol 58: 1-6. doi:10.1016/j.humpath.2016.07.020. PMID 27498062.
  4. Xie, WL.; Lian, JY.; Li, B.; Tian, XY.; Li, Z. (Apr 2017). "Mixed epithelial and stromal tumor of kidney with renal vein extension: an unusual case report and review of literature.". Histol Histopathol 32 (4): 361-369. doi:10.14670/HH-11-800. PMID 27383188.