Difference between revisions of "Aneurysmal bone cyst"

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'''Aneurysmal bone cyst''' is a very common benign pathology of [[bone]].
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Aneurysmal_bone_cyst_-_intermed_mag.jpg
| Width      =
| Caption    = Aneurysmal bone cyst. [[H&E stain]].
| Synonyms  =
| Micro      =
| Subtypes  =
| LMDDx      = [[giant cell tumour of bone]], [[telangiectatic osteosarcoma]], other [[giant cell lesions]]
| Stains    =
| IHC        =
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Site      = [[bone]]
| Assdx      =
| Syndromes  =
| Clinicalhx =
| Signs      =
| Symptoms  =
| Prevalence = common
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = benign
| Other      =
| ClinDDx    =
| Tx        =
}}
'''Aneurysmal bone cyst''', abbreviated '''ABC''', is a very common benign pathology of [[bone]].


*Abbreviated ''ABC''.
'''[[Giant cell reparative granuloma]]''' (also known as ''solid aneurysmal bone cyst'') is dealt with separately.
:''Also see [[giant cell reparative granuloma]]'' ([[AKA]] ''solid aneurysmal bone cyst'').


==General==
==General==
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<gallery>
<gallery>
Image:Aneurysmal_bone_cyst_-_intermed_mag.jpg | ABC - intermed. mag. (WC/Nephron)
Image:Aneurysmal_bone_cyst_-_intermed_mag.jpg | ABC - intermed. mag. (WC/Nephron)
Image:Aneurysmal_bone_cyst_-_high_mag.jpg | ABC - high mag. (WC/Nephron)
Image:Aneurysmal_bone_cyst_-_very_high_mag.jpg | ABC - very high mag. (WC/Nephron)
Image:Aneurysmal_bone_cyst_-_very_high_mag.jpg | ABC - very high mag. (WC/Nephron)
Image:[[File:Bone AneurysmalBoneCyst HP.JPG|thumb|High power view of giant cells in a less cellular version of aneurysmal bone cyst.]]
</gallery>
</gallery>
www:
www:

Latest revision as of 02:47, 3 December 2014

Aneurysmal bone cyst
Diagnosis in short

Aneurysmal bone cyst. H&E stain.
LM DDx giant cell tumour of bone, telangiectatic osteosarcoma, other giant cell lesions
Site bone

Prevalence common
Prognosis benign

Aneurysmal bone cyst, abbreviated ABC, is a very common benign pathology of bone.

Giant cell reparative granuloma (also known as solid aneurysmal bone cyst) is dealt with separately.

General

Features:[1]

  • Benign.
    • May grow rapidly.
  • Osteolysis -> cystic space -> filled with blood.
  • Relatively common; in children second only to osteosarcoma.[2]

Gross/radiologic

Features:[3]

  • Air-fluid levels (radiology).
  • Usually metaphysis of long bones, but uncommonly the femur.
  • May have an "aggressive" appearance, i.e. erode bone.

Microscopic

Features:[1]

  • Bony trabeculae or osteoid tissue.
  • Osteoclast giant cells.
    • Multi-nucleated giant-cells with round randomly arranged nuclei.
  • Benign spindle cells (fibroblasts) - surround bone/adjacent to the giant cells - important.
  • Blood +/- surrounded by giant cells.

DDx:

Images

www:

See also

References

  1. 1.0 1.1 URL: http://emedicine.medscape.com/article/1254784-overview. Accessed on: 4 February 2011.
  2. van den Berg H, Kroon HM, Slaar A, Hogendoorn P (2008). "Incidence of biopsy-proven bone tumors in children: a report based on the Dutch pathology registration "PALGA"". J Pediatr Orthop 28 (1): 29–35. doi:10.1097/BPO.0b013e3181558cb5. PMID 18157043.
  3. Parashari, UC.; Khanduri, S.; Upadhyay, D.; Bhadury, S.; Singhal, S.. "Radiologic and pathologic correlation of aneurysmal bone cysts at unusual sites.". J Cancer Res Ther 8 (1): 103-5. doi:10.4103/0973-1482.95183. PMID 22531523.