Anaplastic pilocytic astrocytoma
Jump to navigation
Jump to search
Anaplastic pilocytic astrocytoma, abbreviated APA, is an outdated tumor terminology. Most of these tumors are now classified either as High-grade astrocytoma with piloid features, Pleomorphic xanthoastrocytoma or as Glioblastoma, IDH-wildtype.
General
- High-grade astrocytoma - behaviour corresponded in older classifications to WHO Grade III.
- Some authors prefered the designation pilocytic astrocytoma with anaplastic features.
- Less than 2% of all pilocytic astrocytomas.[1]
- De novo cases in the setting of neurofibromatosis 1 reported.
- Many tumors have history of previous radiation.
Old microscopic criteria
Features:[2]
- At least 4 mitoses/10 high power fields - see HPFitis.
- Hypercellularity.
- Necrosis +/-.
- Pilocytic like (biphasic) - most common.
- Eosinophilic granular bodies +/-.
- Small cell (32%)
- Epithelioid cells (15%)
- Fibrillary areas resembling diffuse astrocytoma.
IHC
Features:[3]
See also
References
- ↑ Rodriguez, FJ.; Scheithauer, BW.; Burger, PC.; Jenkins, S.; Giannini, C. (Feb 2010). "Anaplasia in pilocytic astrocytoma predicts aggressive behavior.". Am J Surg Pathol 34 (2): 147-60. doi:10.1097/PAS.0b013e3181c75238. PMID 20061938.
- ↑ Rodriguez, FJ.; Scheithauer, BW.; Burger, PC.; Jenkins, S.; Giannini, C. (Feb 2010). "Anaplasia in pilocytic astrocytoma predicts aggressive behavior.". Am J Surg Pathol 34 (2): 147-60. doi:10.1097/PAS.0b013e3181c75238. PMID 20061938.
- ↑ Rodriguez, FJ.; Scheithauer, BW.; Burger, PC.; Jenkins, S.; Giannini, C. (Feb 2010). "Anaplasia in pilocytic astrocytoma predicts aggressive behavior.". Am J Surg Pathol 34 (2): 147-60. doi:10.1097/PAS.0b013e3181c75238. PMID 20061938.
- ↑ Ebrahimi, A.; Skardelly, M.; Bonzheim, I.; Ott, I.; Mühleisen, H.; Eckert, F.; Tabatabai, G.; Schittenhelm, J. (Jun 2016). "ATRX immunostaining predicts IDH and H3F3A status in gliomas.". Acta Neuropathol Commun 4 (1): 60. doi:10.1186/s40478-016-0331-6. PMID 27311324.